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GenomicsGenome-wide CRISPR knockout screen in Mycobacterium tuberculosis infected macrophages to identify regulators of TNF and iNOS expression
To elucidate the early regulators of inflammation during Mycobacterium tuberculosis infection, we performed a genome-wide CRISPR knockout screen in macrophages to identify genes that influence the induction of TNF and iNOS upon infection. A genome-wide knockout library in murine macrophages was infe...
ORGANISM(S): Mus musculus 
2026-04-29 | E-MTAB-15739 | biostudies-arrayexpress
GenomicsGenome-wide CRISPR knockout screen to identify genes involved in macrophage differentiation
To identify genes involved in macrophage differentiation, a genome-wide CRISPR knockout library in macrophage progenitors was differentiated into macrophages. Samples were collected from the progenitor library at day 0, from a library maintained as progenitors for seven days, and from macrophages af...
ORGANISM(S): Mus musculus 
2026-04-29 | E-MTAB-15740 | biostudies-arrayexpress
GenomicsGenome-wide CRISPR-Cas9 knockout screen in MCF10A with ATP-competitive inhibition of CDC7 (XL-413)
The coordinated activation of DNA replication origins is important for efficient DNA synthesis and genome stability. S-phase cyclin dependent kinases (CDKs) together with CDC7 kinase, are essential to origin activation by converting the pre-replicative complex into a fully active helicase. To identi...
ORGANISM(S): Homo sapiens 
2026-09-30 | E-MTAB-17434 | biostudies-arrayexpress
MetabolomicsA genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy(Part 1)
Not available
ORGANISM(S): Homo sapiens 
ST002085 | MetabolomicsWorkbench
MetabolomicsA genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy(Part 2)
Not available
ORGANISM(S): Homo sapiens 
ST002084 | MetabolomicsWorkbench
TranscriptomicsCRISPR screen exploring resistance to AKTi (Capivasertib) in ER+ Breast Cancer in MCF7, T47D and CAMA-1 cell lines
A genome-wide CRISPR-Cas9 knockout screen was performed in the breast cancer cell lines T47D, MCF7, and CAMA-1 to identify genes modulating sensitivity and resistance to capivasertib, a selective AKT inhibitor. Cells were transduced with a CRISPR library, followed by treatment with capivasertib or v...
ORGANISM(S): Homo sapiens 
2026-05-25 | E-MTAB-16438 | biostudies-arrayexpress
GenomicsAmplicon Sequencing of gRNAs from Brunello CRISPR mutagenized A549 and U87-MG cells after live/dead selection with EV-D68 IL
With the near eradication of poliovirus due to global vaccination campaigns, attention has shifted to other enteroviruses that can cause polio-like paralysis syndrome (now termed acute flaccid myelitis (AFM)). In particular, enterovirus D68 (EV-D68) is believed to be the main driver of epidemic outb...
ORGANISM(S): Homo sapiens 
2025-02-25 | E-MTAB-14765 | biostudies-arrayexpress
GenomicsCRISPR screen M14 NCI H3122
Genome wide CRISPR screen was performed to find resistance to targeted drugs for melanoma and lung
EGAS00001001060 | EGA
GenomicsAmplicon sequencing data of sgRNA cassettes from pig CRISPR screening time course to identify essential genes in PK15 and IPEC-J2 cell lines
This study describes a genome-wide CRISPR-Cas9 knockout (GeCKO) screen performed in two porcine cell lines, PK15 and IPEC-J2. A custom-designed porcine GeCKO (pGeCKO) library targeting protein-coding genes, lncRNAs, and miRNAs was used. Genomic DNA was harvested from GeCKO cell populations at four t...
ORGANISM(S): Salmo salar 
2025-08-30 | E-MTAB-15487 | biostudies-arrayexpress
GenomicsGlioblastoma CRISPR Screen
This is an in vitro genome-wide CRISPR/cas9 screen in human glioblastoma stem cells, screening for genes essential for survival of these cells. These cells express cas9 and have been transfected with a guide RNA library causing gene knockouts. We will analyse the sequencing data for depletion of gui...
EGAS00001001519 | EGA
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