Crl4 - OmicsDI

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CRL4(CRBN) ubiquitin ligase profiling

In the 1950s the drug thalidomide administered as a sedative to pregnant women led ot the birth of thousands of children with multiple defects. Despite its teratogenicity, thalidomide and ist IMiD derivatives recently emerged as effective treatments for multiple myeloma and 5q-dysplasia. IMiDs targe...

ORGANISM(S): Homo sapiens

2014-05-13 | E-GEOD-57554 | biostudies-arrayexpress

Structure and mechanism of a novel cytomegaloviral DCAF mediating interferon antagonism

Human cytomegalovirus (CMV) is a highly relevant pathogen, and its rodent counterparts serve as common infection models. Global proteome profiling of rat CMV (RCMV)-infected cells uncovered a pronounced loss of the transcription factor STAT2, which is crucial for interferon signalling. Deletion muta...

ORGANISM(S): Cellular Organisms

2022-12-15 | PXD033366 | JPOST Repository

CRL4(CRBN) ubiquitin ligase profiling

ORGANISM(S): Homo sapiens

2014-05-13 | GSE57554 | GEO

Homo sapiens

CRL4(CRBN) ubiquitin ligase profiling

PRJNA246700 | ENA

CRL4-DCAF15 control of cohesin dynamics sustains cell proliferation [HiC]

PRJNA1008732 | ENA

CRL4-Cereblon complex in Thalidomide Embryopathy: a translational investigation.

Not available