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ProteomicsExpression of Siglec-E alters the proteome of LPS-activated macrophages but does not affect LPS-driven cytokine production or TLR4 endocytosis Expression of Siglec-E alters the proteome of LPS-activated macrophages but does not affect LPS-driven cytokine production or TLR4 endocytosis
Siglec-E is a murine CD33-related siglec that functions as an inhibitory receptor and is expressed mainly on neutrophils and macrophage populations. Recent studies have suggested that siglec-E is an important negative regulator of LPS-TLR4 signalling and one report (Wu et al 2016) claimed that sigl...
ORGANISM(S): Mus musculus (Mouse) 
2018-02-09 | PXD008406 | Pride
Mouse bmdm lc-msms 
ProteomicsProteomics of Treg membrane proteins
The aim of this project is to identify total membrane proteins on rest and activated regulatory T cells.
ORGANISM(S): Mus musculus (Mouse) 
2021-04-28 | PXD021737 | Pride
Treg Membrane proteins 
ProteomicsProximity labeling of Siglec-1 counter-receptors on activated regulatory T cells using soluble Siglec-1-HRP multimers
Siglec-1 is a macrophage lectin-like receptor that mediates sialic acid-dependent cellular interactions. It was shown previously to promote inflammation in autoimmune disease through suppressing the expansion of regulatory T cells (Tregs). We have investigated the molecular basis for Siglec-1 bindin...
ORGANISM(S): Armoracia rusticana Mus musculus (Mouse) Homo sapiens (Human) 
2021-04-28 | PXD021693 | Pride
Proximity labeling Counter-receptor Siglec-1 
ProteomicsProximity labeling of Siglec-1 counter-receptors on activated regulatory T cells using Siglec-1-HRP multimers on nano-beads
Siglec-1 is a macrophage lectin-like receptor that mediates sialic acid-dependent cellular interactions. It was shown previously to promote inflammation in autoimmune disease through suppressing the expansion of regulatory T cells (Tregs). We have investigated the molecular basis for Siglec-1 bindin...
ORGANISM(S): Armoracia rusticana Mus musculus (Mouse) Homo sapiens (Human) 
2021-04-28 | PXD021691 | Pride
Proximity labeling Counter-receptor Siglec-1 
ProteomicsProteomic analysis of rest and activated Tregs
The aim of the project is to do proteomic analysis of total cell lysate from rest and activated mouse Tregs. The proteomic data were mapped to the Gene Ontology Cellular Component (GOCC)database to obtain the list of membrane proteins on activated Tregs. The set of membrane proteins identified were ...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-28 | PXD022259 | Pride
Proteomics Treg 
UnknownDesign innovations and baseline findings in a long-term Parkinson's trial: the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson's Disease Long-Term Study-1.
Not available
S-EPMC3481179 | biostudies-literature
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