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ProteomicsCellular Senescence in Progenitor Cells Contributes to Diminished Remyelination Potential in Progressive Multiple Sclerosis
Cellular senescence is a form of adaptive cellular physiology associated with aging. Cellular senescence causes a pro-inflammatory cellular phenotype that impairs tissue regeneration, has been linked to stress, and is implicated in several human neurodegenerative diseases. We had previously determin...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD013060 | Pride
Proteomics Oligodendrocyte Neural progenitor cells Aging Rapamycin 
ProteomicsAstrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age
Extracellular vesicles isolated from the conditioned media of short, long-term, and rapamycin treated long-term cultured astrocytes were subjected to proteomic analysis to determine the how the EV proteome changes following long-term culture.
ORGANISM(S): Mus musculus (Mouse) 
2020-05-27 | PXD017058 | Pride
Astrocytes Senescence Extracellular vesicles Oligodendrocytes 
ProteomicsExtracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis
Extracellular vesicles isolated from murine and human patient blood plasma was subjected to proteomic analysis to determine the EV proteome in healthy, non-disease murine and human samples and during disease.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-09-27 | PXD013630 | Pride
Extracellular vesicles Human Multiple sclerosis Fibrinogen 
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