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MetabolomicsMetabonomics of human fecal extracts characterize ulcerative colitis, Crohn's disease and healthy individuals
This study employs spectroscopy-based metabolic profiling of fecal extracts from healthy subjects and patients with active or inactive ulcerative colitis (UC) and Crohn's disease (CD) to substantiate the potential use of spectroscopy as a non-invasive diagnostic tool and to characterize the fecal me...
2017-02-07 | MTBLS237 | MetaboLights
MetabolomicsGut Microbiota and Bile Acids Profiles study of Ulcerative Colitis and Crohn's Disease Patients

The global incidence of inflammatory bowel disease (IBD) is increasing, with dysbiosis of the gut microbiota identified as a significant factor contributing to chronic intestinal inflammation. This study aims to elucidate the gut microbiota and serum bile acid profiles in patients with ulcerative...

2026-03-19 | MTBLS14084 | MetaboLights
MetabolomicsGut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives.

BACKGROUND & AIMS: The cause of Crohn's disease (CD) is unknown, but the current hypothesis is that microbial or environmental factors induce gut inflammation in genetically susceptible individuals, leading to chronic intestinal inflammation. Case-control studies of patients...

2023-11-16 | MTBLS300 | MetaboLights
MetabolomicsShort-Term Clinical Response and Changes in the Fecal Microbiota and Metabolite Levels in Patients with Crohn's Disease After Stem Cell Infusions
Recent studies have shown a close relationship between the gut microbiota and Crohn's disease (CD). This study aimed to determine whether mesenchymal stem cell (MSC) treatment alters the gut microbiota and fecal metabolite pathways and to establish the relationship between the gut microbiota and fec...
2025-07-03 | MTBLS6288 | MetaboLights
MetabolomicsMetabonomics uncovers a reversible proatherogenic lipid profile during infliximab therapy of inflammatory bowel disease

BACKGROUND: One-third of inflammatory bowel disease (IBD) patients show no response to infliximab (IFX) induction therapy, and approximately half of patients responding become unresponsive over time. Thus, identification of potential treatment response biomarkers are of great cl...

2022-01-13 | MTBLS239 | MetaboLights
TranscriptomicsTranscription profiling of human macrophages from Crohns disease patients or healthy control individuals, either unstimulated or stimulated with heat killed E. coli;
Comparison of gene expression in macrophages from Crohn's disease patients or healthy control individuals, either unstimulated or stimulated with heat killed E. coli
ORGANISM(S): Homo sapiens 
2009-08-03 | E-TABM-733 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human ileum and colonic tissues from patients with Crohns disease or ulcerative colitis
Samples for microarray analysis were derived from terminal ileum and colonic tissues from probands with Crohn's disease and Ulcerative Colitis and control patients, respectively. IBD tissue biopsies from non-inflamed regions 10 cm distant from pathological areas were selected. To minimize inter-indi...
ORGANISM(S): Homo sapiens 
2007-08-03 | E-GEOD-1152 | biostudies-arrayexpress
ProteomicsMetaproteomic study about diet-induced effects on the gut microbiota of patients affected by Crohn's disease
Metaproteomic study on fecal samples collected from Crohn's Disease (CD) patients and some Household Healthy Controls (HHC) during an eight week Lof Fat/High fiber diet intervention. Stoo sampling was performed at baseline (V1), week 8 (V2) and week 36 (V3). Protein Identification and quantitation ...
ORGANISM(S): Bacteria Homo Sapiens (ncbitaxon:9606) 
2024-02-01 | MSV000093975 | MassIVE
no omics definedTranscription profiling of human ileal epithilium in patients suffering from Crohn's disease
Identification of significant regulated genes of the ileal epithelium in patients suffering from Crohn disease (normal vs. activ and non activ CD).
ORGANISM(S): Homo sapiens 
2009-02-27 | E-MEXP-1225 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of jejunal tissue from patients with Crohn's disease compared with non-inflammatory bowel disease patients
The entire small intestine was observed by balloon endoscopy. Biopsy specimens were taken from jejunum, ileum and colon, respectively. Four Crohn's disease patients and four healthy controls were compared.
ORGANISM(S): Homo sapiens 
2015-06-11 | E-GEOD-69762 | biostudies-arrayexpress
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