Sort   by:  
 Page size 
TranscriptomicsMultivalent Influenza DNA vaccine induces cross-reactive polyfunctional T lymphocytes and promotes rapid clearance of heterologous challenge strain in non-human primates
Recent avian and swine-origin influenza virus outbreaks illustrate the ongoing threat of influenza pandemic. New vaccines that offer accelerated production and broader, more universal protection against drifted and shifted strains are needed. Here, we investigated a multivalent PMED DNA vaccine for...
ORGANISM(S): Macaca fascicularis 
2016-07-31 | E-GEOD-77824 | biostudies-arrayexpress
TranscriptomicsDefective Mitophagy in XPA via PARP1 activation and NAD+/SIRT1-depletion: Implications for neurodegeneration (mouse)
Mitochondrial dysfunction is a common feature in neurodegeneration and aging. We identify mitochondrial dysfunction in xeroderma pigmentosum group A (XPA), a nucleotide excision DNA repair disorder with severe neurodegeneration, in silico and in vivo. XPA deficient cells show defective mitophagy wit...
ORGANISM(S): Mus musculus 
2015-06-04 | E-GEOD-55485 | biostudies-arrayexpress
GenomicsGenome-wide mapping of FOXM1 binding reveals co-binding with oestrogen receptor alpha in breast cancer cells (ChIP-seq)
The forkhead transcription factor FOXM1 is a key regulator of the cell cycle and is overexpressed in cancer. Increased levels of FOXM1 are associated with both poor prognosis and oestrogen receptor (ERalpha) status in primary breast cancer. In this study, we map FOXM1 binding genome wide in both ERa...
ORGANISM(S): Homo sapiens 
2013-01-07 | E-GEOD-40762 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of late exponential vs. stationary phase cultures using a custom designed Pseudo-nitzschia multiseries (Ps-n) cDNA microarray
Pseudo-nitzschia multiseries (Ps-n) is a toxigenic marine diatom that produces the neurotoxin, domoic acid. We screened for candidate genes that may be involved in domoic acid production by determining changes in transcript profiles in Ps-n cultures that were in late exponential (low-domoic-acid-pro...
ORGANISM(S): Pseudo-nitzschia multiseries 
2013-09-08 | E-GEOD-46845 | biostudies-arrayexpress
UnknownAwareness and preparedness of healthcare workers against the first wave of the COVID-19 pandemic: A cross-sectional survey across 57 countries.
Not available
S-EPMC8694437 | biostudies-literature
Sort   by:  
 Page size