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MetabolomicsDifferent Metabolic Pathways Associated With Total Cortisol Exposure and the Cortisol Time Profile: A Randomized Crossover Trial

Excess cortisol exposure and disruption of the circadian cortisol profile are both associated with adverse clinical outcomes. The aim of this study was to identify unique metabolites and metabolic pathways associated with total cortisol exposure and/or variation of the cortisol time profile. Eigh...

2026-01-16 | MTBLS13147 | MetaboLights
MetabolomicsIdentification and validation of poly-metabolite scores for diets high in ultra-processed food: An observational study and post-hoc randomized controlled crossover-feeding trial.

BACKGOUND: Ultra-processed food (UPF) accounts for a majority of calories consumed in the United States, but the impact on human health remains unclear. We aimed to identify poly-metabolite scores in blood and urine that are predictive of UPF intake.

METHODS AND FIN...

2025-07-12 | MTBLS12705 | MetaboLights
TranscriptomicsSpo11-oligo mapping in S. cerevisiae Ctf19/CCAN kinetochore sub-complex mutant mcm21
During meiosis, crossover recombination is essential to link homologous chromosomes and drive faithful chromosome segregation. Crossover recombination is non-random across the genome, and centromere-proximal crossovers are associated with an increased risk of aneuploidy, including Trisomy 21 in huma...
ORGANISM(S): Saccharomyces cerevisiae 
2015-12-15 | E-GEOD-72683 | biostudies-arrayexpress
TranscriptomicsUnexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract: an Experimental Crossover Study
Intravaginal HIV microbicides could provide women with a self-controlled means for HIV prevention, but results from clinical trials have been largely disappointing. We postulated that unrecognized effects of intravaginal gels on the upper female reproductive tract (FRT) might contribute to the lower...
ORGANISM(S): Homo sapiens 
2015-08-10 | E-GEOD-58090 | biostudies-arrayexpress
UnknownCosts of Specialist Referrals From Employer-Sponsored Integrated Health Care Clinics Are Lower Than Those From Community Providers.
Not available
S-EPMC9321287 | biostudies-literature
GenomicsMeiotic crossover landscape within RAC1 disease resistance gene
To study recombination at the fine-scale, we used high-throughput sequencing of 300 to 1,000 crossovers within the RAC1 R gene hotspot. This revealed focused intragenic crossovers, overlapping exons encoding the TIR, NBS and LRR domains. To examine the role of recombination pathways, we repeated thi...
ORGANISM(S): Arabidopsis thaliana 
2018-07-01 | E-MTAB-6333 | biostudies-arrayexpress
Genomicsmeiotic crossover analysis from F1 mouse sperm
meiotic crossover analysis from F1 mouse sperm
PRJEB85615 | ENA
GenomicsGlobal Analysis of the Meiotic Crossover Landscape
Using microarrays to genotype the parental origin of progeny resulting from a cross between S96 and YJM789 yeast strains, we mapped the distribution of crossovers that occurred during meiosis. Knowledge of the crossover distribution allowed us to assess changes in crossover control in wild type and ...
ORGANISM(S): Saccharomyces cerevisiae 
2008-09-16 | GSE12170 | GEO
GenomicsMeiotic crossover landscape within RAC1 disease resistance gene
Meiotic crossover landscape within RAC1 disease resistance gene
PRJEB24064 | ENA
GenomicsA meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation
Meiotic crossover formation requires the stabilization of early recombination intermediates by a set of proteins and occurs within the environment of the chromosome axis, a structure important for the regulation of meiotic recombination events. The molecular mechanisms underlying and connecting cros...
ORGANISM(S): Saccharomyces cerevisiae 
2018-02-14 | GSE103877 | GEO
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