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TranscriptomicsDefective Mitophagy in XPA via PARP1 activation and NAD+/SIRT1-depletion: Implications for neurodegeneration (mouse)
Mitochondrial dysfunction is a common feature in neurodegeneration and aging. We identify mitochondrial dysfunction in xeroderma pigmentosum group A (XPA), a nucleotide excision DNA repair disorder with severe neurodegeneration, in silico and in vivo. XPA deficient cells show defective mitophagy wit...
ORGANISM(S): Mus musculus 
2015-06-04 | E-GEOD-55485 | biostudies-arrayexpress
ProteomicsNicotinamide riboside modulates the reactive species interactome, bioenergetic status and proteomic landscape in a brain-region-specific manner
Nicotinamine riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD+), has robust behavioral and cognitive benefits as well as effects alleviating neuroinflammation in AD mouse models. Gene expression studies hint benefitial induction of neuroprotective pathways for AD. However, the pr...
ORGANISM(S): Mus Musculus 
PXD053897 |
TranscriptomicsA High-Fat Diet and NAD+ Rescue Premature Aging in Cockayne Syndrome
Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in the genes encoding the DNA repair proteins CSA or CSB. Csbm/m mice were given a high-fat, caloric-restricted or resveratrol-supplemented diet. The high-fat diet rescued the p...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-62194 | biostudies-arrayexpress
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