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TranscriptomicsExpression Data from WT and Sh2d1a-/- in vivo follicular helper CD4 T cells (TFH) versus non follicular helper CD4 T cells (non-TFH)
CD4 T cell help is critical for both the generation and maintenance of germinal centers, and T follicular helper (TFH) cells are the CD4 T cell subset required for this process. SAP (SH2D1A) expression in CD4 T cells is essential for germinal center development. However, SAP-deficient mice have only...
ORGANISM(S): Mus musculus 
2010-04-28 | E-GEOD-21379 | biostudies-arrayexpress
UnknownT follicular helper cell differentiation, function, and roles in disease.
Not available
S-EPMC4223692 | biostudies-literature
TranscriptomicsTranscriptome analysis of early differentiating Tfh vs Th1 cells
Comparison of transcriptome between early Tfh vs. early Th1 cells Blimp-1-YFP LCMV gp specific TCRtg Smarta cells were transferred into B6 mice, which were then infected with LCMV Armstrong. On day 3 after infection, splenocytes were stained to sort Blimp-1-YFP+IL-2Ra+ Th1 cells or Blimp-1-YFP-IL-2R...
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-67334 | biostudies-arrayexpress
TranscriptomicsImpact of Lef1 overexpression on follicular helper T (Tfh) differentiation
Comparison of transcriptome between GFP-RV+ Th1 cells and Lef1-RV+ Th1 cells B6 mice received GFP-RV+ or Lef1-RV+ LCMV gp specific TCRtg Smarta cells and were infected with LCMV. On four days after infection, splenocytes were collected to sort CXCR5- Th1 cells per genotype. Contributor: LIAI RNAi Ce...
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-67335 | biostudies-arrayexpress
TranscriptomicsActivin A regulates human T follicular helper (Tfh) cell differentiation
To determine the role of the cytokine activin A in the regulation of human T follicular helper (Tfh) cell gene program, we performed a transcriptomic analysis (RNA-seq) of human naïve CD4 T cells differentiated in vitro with activin A. The analysis of the gene expression profile driven by activin A...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-78276 | biostudies-arrayexpress
UnknownCutting edge: T follicular helper cell differentiation is defective in the absence of Bcl6 BTB repressor domain function.
Not available
S-EPMC4456636 | biostudies-literature
UnknownAdaptive immunity to SARS-CoV-2 and COVID-19.
Not available
S-EPMC7803150 | biostudies-literature
UnknownHIV vaccinology: 2021 update.
Not available
S-EPMC8463426 | biostudies-literature
TranscriptomicsGerminal center T follicular helper cell IL-4 production is dependent on SLAM receptor (CD150)
CD4 T cell help is critical for both the generation and maintenance of germinal centers, and T follicular helper (TFH) cells are the CD4 T cell subset required for this process. SAP (SH2D1A) expression in CD4 T cells is essential for germinal center development. However, SAP-deficient mice have only...
ORGANISM(S): Mus musculus 
2010-04-28 | E-GEOD-21381 | biostudies-arrayexpress
TranscriptomicsExpression Data from in vivo Tfh vs GC Tfh vs non-Tfh
CD4 T cell help is critical for both the generation and maintenance of germinal centers, and T follicular helper (TFH) cells are the CD4 T cell subset required for this process. SAP (SH2D1A) expression in CD4 T cells is essential for germinal center development. However, SAP-deficient mice have only...
ORGANISM(S): Mus musculus 
2010-04-28 | E-GEOD-21380 | biostudies-arrayexpress
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