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Transcriptomicsarray-CGH on single blastomeres from day-4 human preimplantation fresh and frozen embryos
In total, 240 single blastomeres from nine top-quality day-4 embryos frozen at day 3 of development and four fresh top-quality day-4 embryos that had one-cell biopsy on day 3 for preimplantation genetic diagnosis (PGD) were collected. Blastomeres' DNA was amplified using SurePlex DNA Amplification S...
ORGANISM(S): Homo sapiens 
2013-04-05 | E-GEOD-39518 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of hiPSC stem cell lines.
The Purpose of this series of experiments is to identify copy number variations, duplications, and deletions in human induced pluripotent stem (hiPSC) cell lines. Genomic DNA of different human induced pluripotent stem cell lines are extracted and hybridized to NimbleGen CGH microarray, using genomi...
ORGANISM(S): Homo sapiens 
2012-01-07 | E-GEOD-33484 | biostudies-arrayexpress
UnknownGenomic and fitness consequences of a near-extinction event in the northern elephant seal.
Not available
S-EPMC11618080 | biostudies-literature
TranscriptomicsPlatform for Induction and Maintenance of Transgene-Free hiPSCs Resembling Ground State Pluripotent Stem Cells
The purpose of this series of experiments is to identify copy number variations, duplications, deletions and regions of homozygosity in human induced pluripotent stem (hiPSC) cell lines. Genomic DNA of human induced pluripotent stem cell lines are extracted and hybridized to Agilent aCGH+SNP microar...
ORGANISM(S): Homo sapiens 
2014-03-03 | E-GEOD-54080 | biostudies-arrayexpress
UnknownApparent expansion of virulent <i>Vibrio parahaemolyticus</i> in humans and sea otters.
Not available
S-EPMC12758354 | biostudies-literature
TranscriptomicsRNA polymerase is poised for activation across the genome
Regulation of gene expression is integral to the development and survival of all organisms. Transcription begins with the assembly of a pre-initiation complex at the gene promoter, followed by initiation of RNA synthesis and the transition to productive elongation. In many cases, recruitment of RNA ...
ORGANISM(S): Drosophila melanogaster 
2007-11-11 | E-GEOD-6714 | biostudies-arrayexpress
UnknownHi-C scaffolded short- and long-read genome assemblies of the California sea lion are broadly consistent for syntenic inference across 45 million years of evolution.
Not available
S-EPMC9732816 | biostudies-literature
TranscriptomicsChIP-chip of MCF7 Sox2 regulatory region 2 transcription activity reporter unresponsive and reporter responsive breast cancer cells
We found that MCF7 and ZR751 Sox2-expressing breast cancer cell lines comprise of cells with heterogeneous Sox2 transcription activity reporter response. A small subset of Sox2 reporter responsive cells are more tumourigenic than the bulk Sox2 reporter unresponsive cells. We questioned whether Sox2 ...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-61703 | biostudies-arrayexpress
TranscriptomicsMicroarray-based CGH in human cancer cell lines
This series represents the data set from the paper Assembly of microarrays for genome-wide measurement of DNA copy number appearing in Nat Genet 2001 Nov;29(3):263-4 and it's web supplement. Specimen procurement, labeling, hybridization and imaging protocols from Nat Genet 2001 Nov;29(3):263-...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-16 | biostudies-arrayexpress
TranscriptomicsGenome-wide alterations in yeast strains lacking RNase H1, RNase H2, or both RNase H1 and RNase H2
Two types of RNA:DNA associations can lead to genome instability: the formation of R-loops during transcription and the incorporation of ribonucleotide monophosphates (rNMPs) into DNA during replication. Both ribonuclease (RNase) H1 and RNase H2 degrade the RNA component of R-loops, whereas only RNa...
ORGANISM(S): Saccharomyces cerevisiae 
2015-09-23 | E-GEOD-73334 | biostudies-arrayexpress
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