Sort   by:  
 Page size 
TranscriptomicsRemodeling of global transcription patterns of C. neoformans genes mediated by stress-activated HOG signaling pathways
The ability to sense and adapt to a hostile host environment is a crucial element for virulence of pathogenic fungi, including Cryptococcus neoformans. These cellular responses are evoked by diverse signaling cascades, including the stress-activated HOG pathway. Despite previous analysis of centra...
ORGANISM(S): Cryptococcus neoformans var. grubii 
2010-05-17 | E-GEOD-16692 | biostudies-arrayexpress
TranscriptomicsThe role of the Ras- and cAMP-signaling pathways in stress response and sterol biosynthesis in Cryptococcus neoformans
The cAMP-pathway plays a central role in regulation of growth, differentiation, and virulence of human pathogenic fungi, including Cryptococcus neoformans. Three major upstream signaling regulators of the adenylyl cyclase (Cac1), Ras, Aca1 (Adenylyl cyclase-associated protein 1) and G-alpha subunit ...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2010-05-22 | E-GEOD-17338 | biostudies-arrayexpress
TranscriptomicsOverexpression of the transcription factor GAT201 in Cryptococcus neoformans var. grubii (serotype A, H99)
Comparison of transcriptional profiles of WT Cryptococcus neoformans (H99) and strain CM126 (pRPL2b-GAT201) which overexpresses the transcription factor GAT201 using a ribosomal protein promoter Keywords: Genetic modification WT vs. CM126 competitive hybridization. 4 biological replicates including...
ORGANISM(S): Filobasidiella neoformans 
2010-05-26 | E-GEOD-10750 | biostudies-arrayexpress
TranscriptomicsHapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans
Analysis of the transcriptional response of C. neoformans WT, cir1 mutant, hap3 mutant and hapX mutant to different iron sources. The following experimental design was adopted for the study. Within each strain, each treatment pair (low-iron, +FeCl3, +Transferrin and +Hemin; 6 pairs) were hybridized ...
ORGANISM(S): Cryptococcus neoformans 
2011-04-13 | E-GEOD-22988 | biostudies-arrayexpress
TranscriptomicsChromosome copy number variation in Cryptococcus neoformans influences virulence and occurs in isolates from AIDS patients
Influence of copy number changes at several chromosomes to melanin production and virulence of Cryptococcus neoformans Black(B4) and white(W2) strains were compared to each other. Black variant from white strain (W2BA1) is also compared to the black strain(B4).
ORGANISM(S): Cryptococcus neoformans 
2011-04-19 | E-GEOD-28673 | biostudies-arrayexpress
TranscriptomicsRole of Cryptococcus neoformans Sre1-pathway in low oxygen gene expression
Comparison of wild-type serotype A C. neoformans cells grown at 21% and 3% oxygen for 2 hours in rich medium. Also comparison of wild-type and Sre1-pathway mutant strains grown at 3 % oxygen for 2 hours in rich medium. Two-condition experiment. Each comparison was performed in two biological replic...
ORGANISM(S): Filobasidiella neoformans 
2010-05-22 | E-GEOD-18282 | biostudies-arrayexpress
ProteomicsMus musculus (A/J) lung infection with Cryptococcus neoformans (serotype A) clinical isolates
To predict the outcomes of disseminated fungal disease, a deeper understanding of host-pathogen interactions at the site of infection is needed to identify targets for clinical intervention and diagnostic development. Cryptococcus neoformans is the causative agent of cryptococcosis, the largest infe...
ORGANISM(S): Cryptococcus neoformans var. grubii Mus musculus (Mouse) 
2025-09-17 | PXD063417 | Pride
Infection Cryptococcus neoformans Mouse Lung Lc-ms/ms 
ProteomicsMrj1HA AP-MS in Cryptococcus neoformans
The opportunistic fungal pathogen Cryptococcus neoformans must adapt to the mammalian environment to establish an infection. Proteins facilitating adaptation to novel environments, such as chaperones, may be required for virulence. In this study, we identified a novel mitochondrial co-chaperone, Mrj...
ORGANISM(S): Cryptococcus neoformans var. grubii H99S 
2020-06-12 | PXD013659 | Pride
Cryptococcus neoformans 
ProteomicsIntegrative proteome and acetylome analyses of murine responses to Cryptococcus neoformans infection
Cryptococcus neoformans, an environmental opportunistic human fungal pathogen, is a causative agent for acute pulmonary infection and meningoencephalitis. Understanding the host’s response to C. neoformans infection is critical for developing effective treatment. Even though some have elucidated the...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-21 | PXD016614 | Pride
Lysine acetylome Mouse lung Cryptococcus neoformans infection Mouse brain 
ProteomicsCryptococcus neoformans LC-MS/MS
Cryptococcus neoformans is an invasive human fungal pathogen, which causes pneumonia and meningoencephalitis in both healthy and immunodeficient individuals, resulting 181,100 deaths each year. Studies have demonstrated that copper detoxification machineries play critical functions in modulating C. ...
ORGANISM(S): Cryptococcus Neoformans Var. Grubii H99 
2021-02-09 | PXD024098 |
Sort   by:  
 Page size