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TranscriptomicsRole of CSN5 in breast cancer
CSN5 has been implicated as a candidate oncogene in human breast cancers by genetic linkage with activation of the poor-prognosis, wound response gene expression signature. CSN5 is a subunit of the eight-protein COP9 signalosome, a signaling complex with multiple biochemical activities; the mechanis...
ORGANISM(S): Homo sapiens 
2010-06-29 | E-GEOD-9206 | biostudies-arrayexpress
TranscriptomicsRole of CSN5 in breast cancer (siRNA transfections)
CSN5 has been implicated as a candidate oncogene in human breast cancers by genetic linkage with activation of the poor-prognosis, wound response gene expression signature. CSN5 is a subunit of the eight-protein COP9 signalosome, a signaling complex with multiple biochemical activities; the mechanis...
ORGANISM(S): Homo sapiens 
2010-06-29 | E-GEOD-9204 | biostudies-arrayexpress
TranscriptomicsRole of CSN5 in breast cancer (array CGH)
CSN5 has been implicated as a candidate oncogene in human breast cancers by genetic linkage with activation of the poor-prognosis, wound response gene expression signature. CSN5 is a subunit of the eight-protein COP9 signalosome, a signaling complex with multiple biochemical activities; the mechanis...
ORGANISM(S): Homo sapiens 
2010-06-29 | E-GEOD-9205 | biostudies-arrayexpress
TranscriptomicsGene expression profile of a S. cerevisiae strain deleted in CSN5/RRI1 gene (systematic name YDL216C)
The COP9 signalosome (CSN) is a highly conserved eukaryotic protein complex which regulates the Cullin-RING family of ubiquitin ligases and carries out a deneddylase activity that resides in subunit 5 (CSN5). The budding yeast CSN is biochemically active and deletion mutants of each of its subunits ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-10-23 | E-GEOD-51563 | biostudies-arrayexpress
TranscriptomicsMCF10A_MYC_PLUS_CSN5
Gene expression signatures encompassing dozens to hundreds of genes have been associated with many important parameters of cancer, but mechanisms of their control are largely unknown. Here we present a method based on genetic linkage that can prospectively identify functional regulators driving larg...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-2824 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis csn3-1, csn4-1 and csn5 (csn5a-2 csn5b) COP9 signalosome (csn) mutant analysis
Transcript profiling analysis of csn3-1, csn4-1 and csn5 (csn5a-2 csn5b) light grown and dark grown mutant seedlings compared to light grown and dark grown wild type using Arabidopsis ATH1 GeneChip array Experiment Overall Design: We compare eight samples of 7 day-old light grown or dark grown csn3-...
ORGANISM(S): Arabidopsis thaliana 
2008-06-16 | E-GEOD-9728 | biostudies-arrayexpress
TranscriptomicsMolecular targeting of CSN5: A mechanism of therapeutic response
Development of targeted therapy for hepatocellular carcinoma (HCC) remains a major challenge. We have recently identified an elevated expression of the fifth subunit of COP9 signalosome (CSN5) in early HCC as compared to dysplastic stage. In the present study, we explored the possibility of CSN5 bei...
ORGANISM(S): Homo sapiens 
2011-12-27 | E-GEOD-26485 | biostudies-arrayexpress
GenomicsCUT&Tag of CSN5 in prostate cancer cells
CUT&Tag of CSN5 in prostate cancer cells
PRJNA725705 | ENA
GenomicsRNA sequencing of CSN5 inhibition in prostate cancer cells
RNA sequencing of CSN5 inhibition in prostate cancer cells
PRJNA725704 | ENA
TranscriptomicsRole of CSN5 in breast cancer
CSN5 has been implicated as a candidate oncogene in human breast cancers by genetic linkage with activation of the poor-prognosis, wound response gene expression signature. CSN5 is a subunit of the eight-protein COP9 signalosome, a signaling complex with multiple biochemical activities; the mechanis...
ORGANISM(S): Homo sapiens 
2008-01-18 | GSE9206 | GEO
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