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TranscriptomicsHigh Glucose (HG) treated morula vs control glucose (CTL) treated morula
Early bovine cleavage (day 0 to 3) was treated with high glucose (5mM) or control glucose (0.2mM) then total day 3 embryos were cultured in control condition until day 5 when gene expression was assessed in developping morula by microarray 4 replicates of 10 morulae/rep was produced for high glucose...
ORGANISM(S): Bos taurus 
2012-09-01 | E-GEOD-40521 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of humoral resistance to the CTL after phenotypical and functional study of the resistant clone IGR-HeuR8
From a tumoral line IGR-Heu; resulting from a biopsy of the primitive tumour of a patient reached of a bronchial cancer not with small cells (NSCLC); we established; by successive co-cultures of this line with the autologous CTL (clone T H161); a resistant line to the cytotoxic lysis induced by H16...
ORGANISM(S): Homo sapiens 
2006-01-23 | E-TABM-71 | biostudies-arrayexpress
TranscriptomicsAAPH-treated blastocysts vs CTL-treated blastocysts
In order to understand how in vitro culture affects embryonic quality, we analyzed survival and global gene expression in bovine blastocysts after exposure to increased oxidative stress conditions of IVC. A pro-oxidant agents that act extra-cellularly by promoting ROS production (0.01 mM 2,2'-azobis...
ORGANISM(S): Bos taurus 
2012-11-14 | E-GEOD-42279 | biostudies-arrayexpress
TranscriptomicsBSO-treated blastocysts vs CTL-treated blastocysts
In order to understand how in vitro culture affects embryonic quality, we analyzed survival and global gene expression in bovine blastocysts after exposure to increased oxidative stress conditions of IVC. A pro-oxidant agents that act intra-cellularly by inhibiting GSH synthesis (0.4 mM buthionine s...
ORGANISM(S): Bos taurus 
2012-11-14 | E-GEOD-42280 | biostudies-arrayexpress
TranscriptomicsAXL targeting overcomes human lung cancer cell resistance to NK and CTL-mediated cytotoxicity
To investigate the effect of AXL inhibition on gene expression in carcinoma cell clones derived from NSCLC IGR-Heu cells, we profiled gene expression in cells treated with the AXL inhibitor bemcentinib (1 µmol/L) or with vehicle (dmso) for 72 hours
ORGANISM(S): Homo sapiens 
2019-10-25 | E-MTAB-8294 | biostudies-arrayexpress
TranscriptomicsExpression data from UKRV-Mel-15a melanoma-derived clones resistant to cytolysis mediated by Melan-A/MART1 (26-35) cytotoxic T lymphocytes (CTL).
Efficient processing of target antigens by the ubiquitin-proteasome-system (UPS) is essential for treatment of cancers by T cell therapies. However, immune escape due to impaired expression of IFN-γ-inducible components of the antigen presentation machinery and consequent inefficient processing of ...
ORGANISM(S): Homo sapiens 
2015-12-12 | E-GEOD-75929 | biostudies-arrayexpress
ModelsWodarz1999 CTL memory response HIV
This a model from the article: Specific therapy regimes could lead to long-term immunological control of HIV. Wodarz D, Nowak MA. Proc Natl Acad Sci U S A 1999 Dec 7;96(25):14464-9 10588728 , Abstract: We...
2024-09-02 | BIOMD0000000683 | BioModels
TranscriptomicsExpression data from control and Phospholipid dependent kinase 1 (PDK1) null cytotoxic T-lymphocytes (CTL) and from control and Akt inhibitor treated CTL
In cytotoxic T cells (CTL), Protein Kinase B /Akt is activated by the T cell antigen receptor (TCR) and the cytokine Interleukin 2 (IL2), in part by phosophorylation of Akt by Phospholipid dependent kinase 1 (PDK1). The role of PDK1 and Akt in CTL has however not been fully defined. In order to expl...
ORGANISM(S): Mus musculus 
2011-02-01 | E-GEOD-26290 | biostudies-arrayexpress
TranscriptomicsHuman tongue squamous cell carcinoma cell line SAS-Control vs. SAS-LYRIC knockdown stable clones global gene profiling
Transcriptional profiling of SAS cells transfected with pLKO.1-LYRIC shRNA-B expression vector (desinaged as B) and control SAS cells (transfected with pLKO.1 vector, designated as CTL). Goal was to determine the effects of LYRIC knockdown on global SAS cells gene expression. Two-condition experimen...
ORGANISM(S): Homo sapiens 
2016-02-28 | E-GEOD-44766 | biostudies-arrayexpress
GenomicsExpression data from CTL and Tc17 cell
Expression data from CTL and Tc17 cell
PRJNA433506 | ENA
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