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ProteomicsTargeting endoplasmic reticulum-anchored CRTH2 binding to LARP6 ameliorates organ fibrosis
Excessive deposition of extracellular matrix, mainly collagen protein, is the hallmark of organ fibrosis. The molecular mechanisms of the regulation of fibrotic protein biosynthesis are unclear. Here, we found that chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2), a cell m...
ORGANISM(S): Mus Sp. 
2021-04-25 | PXD025610 |
ProteomicsBCAA insufficiencies lead to premature ovarian insufficiency via ceramide induced elevation of ROS
Premature ovarian insufficiency (POI) is a disease featured by early menopause before 40 years of age, accompanied by an elevation of follicle-stimulating hormone (FSH). Though POI affects many aspects of women’s health, its major causes remain unknown. Many clinical studies have shown that POI pati...
ORGANISM(S): Homo Sapiens 
2022-10-13 | PXD037353 |
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