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TranscriptomicsGene expression profiles of H16N2 cells expressing EZH2 variants
A cytosolic role for EZH2 in regulating cell signaling via interaction with the VAV family of proteins has been reported by us previously. However, it is unclear whether EZH2 interactions with VAV are critical for tumorigenesis. Here, we show that cytosolic EZH2 exhibits greater transforming/metasta...
ORGANISM(S): Homo sapiens 
2017-10-04 | E-MTAB-3599 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of pancreatic progenitors differentiated from H9 human embryonic stem cells and induced pluripotent stem cells derived from a Mitchell-Riley Syndrome patient
Skin biopsies were obtained from a patient with Mitchell-Riley syndrome caused by a homozygous frame-shift mutation (c.1129C>T) in the RFX6 gene that leads to a premature stop codon (p.Arg377X). The patient suffered severe pancreatic agenesis, in common with other Mitchell-Riley syndrome patients. F...
ORGANISM(S): Homo sapiens 
2020-03-30 | E-MTAB-6626 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of DA neurons, human midbrain-like organoids and prenatal midbrain
Recent advances in three dimensional (3D) culture systems have led to the generation of brain organoids that share resemblance to different parts of the human brains; however, a 3D organoid model of the midbrain that contains functional midbrain dopaminergic (mDA) neurons has not been reported. In t...
ORGANISM(S): Homo sapiens 
2016-08-24 | E-MTAB-4868 | biostudies-arrayexpress
TranscriptomicsRNA-Seq profiling of dopaminergic neurons from iPSCs of Parkinson's disease patients
The fact that Parkinsons disease (PD) can arise from numerous genetic mutations suggests a unifying molecular pathology underlying the various genetic backgrounds. In order to address this hypothesis, an integrated approach utilizing in vitro disease modeling and comprehensive transcriptome profilin...
ORGANISM(S): Homo sapiens 
2016-06-07 | E-MTAB-4586 | biostudies-arrayexpress
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