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TranscriptomicsTranscription profiling of human glucose-dependent insulinotropic peptide (GIP)- and adrenocorticotropin-dependent adrenal hyperplasias reveals novel targets for the study of GIP-dependent Cushings syndrome.
The mechanisms responsible for the ectopic adrenal expression of glucose-dependent insulinotropic peptide (GIP) receptor (GIPR) in GIP-dependent Cushing's syndrome (CS) are unknown. Chronic adrenal stimulation by ACTH in Cushing's disease or GIP in GIP-dependent ACTH-independent macronodular adrenal...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-4060 | biostudies-arrayexpress
GenomicsSmall RNA-seq analysis of circulating miRNAs in Cushing's syndrome
Small RNA-seq analysis of circulating miRNAs in Cushing's syndrome
PRJNA1132695 | ENA
GenomicsSmall RNA-seq analysis of circulating miRNAs in Cushing's syndrome
Patients with Cushing’s syndrome (Cushing's syndrome) in remission show sustained fatigue, myopathy, and an increased prevalence of sarcopenia. The mechanisms that determine these persistent muscle problems are not well known. We aimed to identify circulating microRNAs (miRNAs) with differential exp...
ORGANISM(S): Homo sapiens 
2024-07-07 | GSE271649 | GEO
UnknownAmenorrhea as a presentation of Cushing's syndrome.
Not available
S-EPMC11301536 | biostudies-literature
ProteomicsDiscovery of a new Cushing’s syndrome PKAc mutant that is retained within anchored type I holoenzymes
Adrenal Cushing’s syndrome is a disease of cortisol hypersecretion often caused by mutations in protein kinase A catalytic subunit (PKAc). Using a personalized medicine screening platform, we discovered a new Cushing’s driver mutation, PKAc-W196G, in ~20% of patient samples analyzed. Proximity prote...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2024-02-10 | PXD045556 | Pride
Cushing's syndrome Pka 
TranscriptomicsThe Cushing's disease adipose gene expression profile reveals effects of long term glucocorticoids on adipose tissue lipid, protein and glucose metabolism
Glucocorticoids have major effects on adipose tissue metabolism. To study tissue mRNA expression changes induced by chronic elevated endogenous glucocorticoids, we performed RNA sequencing on subcutaneous adipose tissue from patients with Cushing’s disease (n=5) compared to patients with non-functio...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-66446 | biostudies-arrayexpress
UnknownIntestinal Perforation in ACTH-Dependent Cushing's Syndrome.
Not available
S-EPMC6436364 | biostudies-literature
UnknownE2F1-mediated human POMC expression in ectopic Cushing's syndrome.
Not available
S-EPMC5152695 | biostudies-literature
GenomicsWhole-exome analysis of corticotropin-independent Cushing's syndrome
We performed WES for 8 cases with corticotropin-independent Cushing’s syndrome, in whom paired tumor and normal DNA was obtained from fresh frozen adenomas and either normal adrenal tissues or peripheral blood, respectively.
EGAS00001000661 | EGA
UnknownMislocalization of protein kinase A drives pathology in Cushing's syndrome.
Not available
S-EPMC9311266 | biostudies-literature
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