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ProteomicsUsing global proteomics to investigate the effect of IQDMA treatment on Leukemic forms of cutaneous T-cell lymphomas (L-CTCL) cells
Leukemic cutaneous T-cell lymphomas (L-CTCL) are lymphoproliferative disorders of skin-homing mature T-cells causing chronic inflammation, tissue destruction, severe infections and sepsis, all linked to poor quality of life and high mortality. Despite numerous sequencing efforts in L-CTCL, recurrent...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035626 | Pride
Global proteomics Kinase Cutaneous t-cell lymphomas (l-ctcl) 
ProteomicsUsing global proteomics to investigate the effect of IQDMA treatment on Leukemic forms of cutaneous T-cell lymphomas (L-CTCL) cells
Leukemic cutaneous T-cell lymphomas (L-CTCL) are lymphoproliferative disorders of skin-homing mature T-cells causing chronic inflammation, tissue destruction, severe infections and sepsis, all linked to poor quality of life and high mortality. Despite numerous sequencing efforts in L-CTCL, recurrent...
ORGANISM(S): Homo sapiens (Human) 
2022-10-06 | PXD035699 | Pride
Cutaneous t-cell lymphoma Kinases 
TranscriptomicsDiagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)
Cutaneous T-cell lymphomas (CTCL) are the most frequent primary skin lymphomas. Nevertheless, diagnosis of early disease has proven difficult due to a clinical and histological resemblance to benign inflammatory skin diseases. To address if microRNA (miRNA) profiling can discriminate CTCL from benig...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-31408 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression in Sézary syndrome: Identification, function and diagnostic potential.
MicroRNAs are commonly aberrantly expressed in many cancers. Very little is known of their role in T-cell lymphoma, however. We therefore elucidated the complete miRNome of purified T-cells cells from 21 patients diagnosed with Sézary syndrome (SzS), a rare aggressive primary cutaneous T-cell (CD4+)...
ORGANISM(S): Homo sapiens 
2010-05-12 | E-GEOD-21697 | biostudies-arrayexpress
TranscriptomicsAurora kinase A is upregulated in cutaneous T-cell lymphoma and represents a potential therapeutic target
Cutaneous T-cell lymphomas form a heterogeneous group of non-Hodgkin lymphomas characterized by only poor prognosis in advanced stage. Despite significant progress made in the identification of novel genes and pathways involved in the pathogenesis of cutaneous lymphoma, the therapeutic value of thes...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-59307 | biostudies-arrayexpress
UnknownBlocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T-cell lymphoma.
Not available
S-EPMC9727928 | biostudies-literature
TranscriptomicsTranscription profiling of human CD4+ cutaneous T-cell lymphoma (CTCL) Sez-4 cell line activated with IL-2, IL-15 or IL-21.
In this study we compared the effects of IL-2, IL-15, and IL-21 on the gene expression, activation of cell signaling pathways, and functional properties of cells derived from the CD4+ cutaneous T-cell lymphoma (CTCL). Whereas both IL-2 and IL-15 that signal through receptors that share the common ga...
ORGANISM(S): Homo sapiens 
2008-04-09 | E-GEOD-8685 | biostudies-arrayexpress
GenomicsPilot study for Illumina TST170 NGS panel on cutaneous T cell lymphoma samples
A number of genomic studies using next generation sequencing (NGS) techniques have attempted to understand the underlying genetic basis of cutaneous T-cell lymphoma and found alterations in genes that are involved in T-cell activation, NF-kB and JAK-signal transducer and activator of transcription (...
EGAS00001002567 | EGA
UnknownBlocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T-cell lymphoma
Not available
S-SCDT-10_15252-EMMM_202115200 | biostudies-other
TranscriptomicsComparison between HuT78 parental and romidpepsin-selected cell lines
Gene expression values were determined for HuT78 parental cells and cells selected with romidpesin in the presence of P-glycoprotein inhibitors. HuT78 DpVp35 cells are maintained in 35 ng/ml romidepsin with 2.5 µg/ml verapamil and HuT78 DpP100 cells are maintained in 100 ng/ml romidepsin with 1 µM v...
ORGANISM(S): Homo sapiens 
2013-03-12 | E-GEOD-45018 | biostudies-arrayexpress
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