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MetabolomicsFour layer multi-omics reveals molecular responses to aneuploidy in Leishmania

Aneuploidy causes system-wide disruptions in the stochiometric balances of transcripts, proteins, and metabolites, often resulting in detrimental effects for the organism. The protozoan parasite Leishmania has an unusually high tolerance for aneuploidy, but the molecular and functional consequenc...

2022-09-19 | MTBLS1612 | MetaboLights
MetabolomicsIntegrated genomic and metabolomic profiling of ISC1, an emerging Leishmania donovani population in the Indian subcontinent

Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontinent (ISC). The disease is lethal without treatment and causes 0.2 to 0.4 million cases each year. Recently, reports of VL in Nepalese hilly districts have increased as well as VL cases cau...

2022-09-15 | MTBLS1606 | MetaboLights
ProteomicsMulti-omics reveals molecular responses to aneuploidy in Leishmania
Integrated genomics, transcriptomics, proteomics and metabolomics experiment of aneuploid Leishmania donovani strains. This submission concerns the proteomic data.
ORGANISM(S): Leishmania donovani Ld 2001 
2022-08-26 | PXD028521 | Pride
Leishmania aneuploidy multiomics proteomics 
TranscriptomicsInvestigation of Gene Expression Changes in Human Umbilical Vein Endothelial cells (HUVECs) following SLC25A13 Knockdown via shRNA Lentiviral Transduction
In this study, we discover an essential role for the mitochondrial glutamate-aspartate antiporter SLC25A13 in biomass synthesis in endothelial cells (ECs). To delineate the global changes of SLC25A13 silencing at a molecular level, we performed high-throughput bulk RNA-sequencing and analyzed the di...
ORGANISM(S): Homo sapiens 
2024-12-31 | E-MTAB-14591 | biostudies-arrayexpress
MetabolomicsEndothelial SLC25A13 links glutamine metabolism to angiogenesis
Attention to exploring endothelial cell (EC) metabolism is increasing, but a holistic perspective on the metabolic adaptations of ECs during angiogenic proliferation, is still missing. Here, we use a previously in-house developed computational EC-adapted genome scale metabolic model that recapitulat...
2026-08-10 | MTBLS15306 | MetaboLights
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