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TranscriptomicsGene expression in undifferentiated or cyclic adenosine monophosphate-exposed BeWo trophoblast cells
BeWo trophoblast cells differentiate in response to expsure to cyclic adenosine monophosphate (cAMP) analogs. Differentiation includes syncytialization (fusion) and hormonogenesis. The goal of this study was to globally determine transcripts differentially expressed in BeWo trophoblast cells followi...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-66840 | biostudies-arrayexpress
MetabolomicsA metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance
Tissues are exposed to diverse inflammatory challenges that shape future inflammatory responses. While cellular metabolism regulates immune function, how metabolism programs and stabilizes immune states within tissues and tunes susceptibility to inflammation is poorly understood. Here, we describe a...
2024-10-25 | MTBLS10416 | MetaboLights
TranscriptomicsDifferentiation of human monocytes to macrophages in the presence of GM-CSF +/- forskolin (FSK)
Macrophages are central mediators of the innate immune system that can be differentiated from monocytes upon exposure to cytokines. While increased cyclic adenosine monophosphate (cAMP) levels inhibit many lipopolysaccharide (LPS) -elicited macrophage inflammatory responses, the effects of elevated ...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-18654 | biostudies-arrayexpress
ProteomicsMutagenesis of Key Phosphodiesterases in Toxoplasma gondii Demonstrates the Plasticity and Therapeutic Potential of Cyclic Nucleotide Signaling
Cyclic nucleotide signaling is pivotal to the asexual growth of T. gondii; however, little do we know about its counter-regulation in this parasite. We identified 18 phosphodiesterase (PDE1-18) enzymes, most of which form apicomplexan-specific clades and lack typical regulatory motifs found in mamma...
ORGANISM(S): Cellular Organisms 
2023-02-22 | PXD032173 | JPOST Repository
TranscriptomicsHelicobacter pylori induce miR-155 in T cells in a cAMP-Foxp3 dependant manner
The human pathogen Helicobacter pylori (Hp) colonizes the gastric epithelium as a unique niche in the stomach. Infections commonly occur in childhood and persist lifelong, leading in some cases to adenocarcinoma and MALT lymphoma. Several studies define mammalian microRNAs as key regulators of the i...
ORGANISM(S): Mus musculus 
2010-12-22 | E-GEOD-18616 | biostudies-arrayexpress
GenomicsChIP-Seq of the Sinorhizobium meliloti CRP-like protein Clr in combination with either cAMP or cGMP under different growth conditions
In bacteria, Crp-Fnr superfamily transcription factors mediate 3',5'-cyclic adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP) signaling. The CRP-like protein Clr of the soil-dwelling and plant-symbiotic α-proteobacterium Sinorhizobium meliloti was previously shown to act...
ORGANISM(S): Sinorhizobium meliloti 
2023-03-23 | E-MTAB-11788 | biostudies-arrayexpress
TranscriptomicsEffect of OVO-like 1 knockdown on global transcript expression in differentiated BeWo trophoblast cells
We had previously discovered that the transcription factor OVO-like 1 (OVOL1) was highly induced during trophoblast differentiation. In this study, we used an lentiviral shRNA strategy to decrease OVOL1 expression in BeWo trophoblast cells. Control cells were transduced with shRNAs targeting no know...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-66962 | biostudies-arrayexpress
TranscriptomicsGene expression in undifferentiated or cyclic adenosine monophosphate-exposed BeWo trophoblast cells
BeWo trophoblast cells differentiate in response to expsure to cyclic adenosine monophosphate (cAMP) analogs. Differentiation includes syncytialization (fusion) and hormonogenesis. The goal of this study was to globally determine transcripts differentially expressed in BeWo trophoblast cells followi...
ORGANISM(S): Homo sapiens 
2015-08-01 | GSE66840 | GEO
TranscriptomicsDiverse effects of cyclic AMP variants on osteogenic and adipogenic differentiation of human mesenchymal stromal cells
Osteogenic differentiation of human mesenchymal stromal cells (hMSCs) may potentially be used in cell-based bone tissue-engineering applications to enhance the bone-forming potential of these cells. Osteogenic differentiation and adipogenic differentiation are thought to be mutually exclusive, and a...
ORGANISM(S): Homo sapiens 
2018-08-05 | E-MTAB-7038 | biostudies-arrayexpress
UnknownCirculating cyclic adenosine monophosphate concentrations in milrinone treated paediatric patients after congenital heart surgery.
Not available
S-EPMC9257900 | biostudies-literature
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