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MetabolomicsPP2Cm Dysregulation Is Associated with Impaired BCAA Catabolism and cGAS-STING Activation in Diabetic Kidney Disease
Background and Aims:Branched-chain amino acids (BCAAs) are increasingly implicated in diabetic kidney disease (DKD), yet the role of protein phosphatase 2C mitochondrial (PP2Cm), encoded by PPM1K and regulating BCAA catabolism through the branched-chain α-ketoacid dehydrogenase (BCKDH) complex, rema...
2026-10-09 | MTBLS15967 | MetaboLights
GenomicsCyclic GMP-AMP synthase and interferon activation diminish MEF2C-mediated cognitive resilience II
Cyclic GMP-AMP synthase and interferon activation diminish MEF2C-mediated cognitive resilience II
PRJNA940108 | ENA
ProteomicsProximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS
Cyclic GMP-AMP synthase (cGAS), as the major DNA sensor, initiates DNA-stimulated innate immune responses and is essential for healthy immune system. Although some regulators of cGAS have been reported, it still remains largely unknown about how cGAS is precisely and dynamically regulated and how ma...
ORGANISM(S): Homo Sapiens 
2023-03-02 | PXD040544 |
GenomicsCyclic GMP–AMP Synthase (cGAS) Deletion Reduces Severity in Bilateral Nephrectomy Mice through Changes in Neutrophil Extracellular Traps and Mitochondrial Respiration
Cyclic GMP–AMP Synthase (cGAS) Deletion Reduces Severity in Bilateral Nephrectomy Mice through Changes in Neutrophil Extracellular Traps and Mitochondrial Respiration
PRJNA911176 | ENA
TranscriptomicsCyclic GMP-AMP synthase and interferon activation diminish MEF2C-mediated cognitive resilience II
Here we report that activation of cyclic GMP-AMP synthase (cGAS) diminishes cognitive resilience by decreasing the neuronal transcriptional network of myocyte enhancer factor 2c (MEF2C) through type I interferon (IFN-I) signaling. Pathogenic tau activates cGAS and IFN-I responses in microglia, in pa...
ORGANISM(S): Mus musculus 
2023-04-26 | GSE226381 | GEO
UnknownThe catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Not available
S-EPMC5699495 | biostudies-literature
GenomicsCyclic GMP-AMP synthase and interferon activation diminish MEF2C-mediated cognitive resilience I
Cyclic GMP-AMP synthase and interferon activation diminish MEF2C-mediated cognitive resilience I
PRJNA940104 | ENA
TranscriptomicsGene induction in STAT1-/- fibroblasts transduced with lentiviruses expressing human cGAS
The hypothesis tested was that lentiviral driven cGAS expression activates antiviral gene expression. Cells were transduced with lentiviruses expressing cGAS or a control (firefly luciferase). Total RNA was harvested 48 h post-transduction and processed for Illumina BeadArray.
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-52241 | biostudies-arrayexpress
TranscriptomicsCyclic GMP–AMP Synthase (cGAS) Deletion Reduces Severity in Bilateral Nephrectomy Mice through Changes in Neutrophil Extracellular Traps and Mitochondrial Respiration
Uremia-induced systemic inflammation is partly caused by the dissemination of microbial molecules such as lipopolysaccharide and bacterial double-stranded DNA from leaked gut damaged by immune cells in response to the microbial molecules. Cyclic GMP–AMP synthase (cGAS) can recognize fragmented DNA a...
ORGANISM(S): Mus musculus 
2023-04-20 | GSE220693 | GEO
GenomicsCyclic GMP-AMP synthase and interferon activation diminish MEF2C-mediated cognitive resilience IV
Cyclic GMP-AMP synthase and interferon activation diminish MEF2C-mediated cognitive resilience IV
PRJNA940106 | ENA
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