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MetabolomicsAberrant accumulation of cyclin D1 rewires glutamine metabolism via loss of IDH3 generating metabolic vulnerability in ESCC and HNSCC

Excessive cyclin D1 accumulation is a frequent oncogenic event in head and neck squamous cell carcinoma (HNSCC) and esophageal squamous cell carcinoma (ESCC). Although classically associated with enhanced proliferation and genomic instability, we reveal that cyclin D1 dysregulation induces unexpe...

2026-08-24 | MTBLS13687 | MetaboLights
TranscriptomicsGene expression data following Cyclin T2 and Cyclin T1 depletion by shRNA in HeLa cells
We have characterized gene expression changes in HeLa cells following long term depletion of Cyclin T2 or Cyclin T1 using shRNA HeLa cells were transduced with VSV-G pseudotyped lentiviral vectors expressing shRNA against either Cyclin T2 or Cyclin T1. As a control, cells were transduced with shRNA...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-28339 | biostudies-arrayexpress
TranscriptomicsCyclin K and cyclin D1b are oncogenic in myeloma cells
To study the oncogenic potential of cyclin D1b in the context of mature B cells we generated several cell clones derived from LP-1 MM cell line expressing either cyclin D1b, Myc or cyclin K oncogenes. Transcriptomic analysis allowed us to describe several mechanisms of cyclin D1b- and K-mediated onc...
ORGANISM(S): Homo sapiens 
2010-04-23 | E-GEOD-15497 | biostudies-arrayexpress
Proteomics,MultiomicsCyclin C-CDK3/8/19 kinases play a tumor-suppressive role in vivo
Cyclin C was cloned as a growth-promoting G1 cyclin1,2, and several studies postulated a role for cyclin C in driving cell proliferation3-8 . Moreover, cyclin C, together with its kinase partner, the cyclin-dependent kinase CDK8, is believed to represent an essential component of basal transcrip...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080728 | MassIVE
TranscriptomicsTranscription profiling by array of human non-activated MM6 cells with cyclin T1 knockdown
Cyclin T1-dependent genes in LPS-activated MM6 cells. HIV-1 is dependent upon cellular co-factors to mediate its replication cycle in CD4+ T cells and macrophages, the two major cell types infected by the virus in vivo. One critical co-factor is Cyclin T1, a subunit of a general RNA polymerase II ...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-10738 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human LPS-activated MM6 cells with Cyclin D1 knockdown
Cyclin T1-dependent genes in LPS-activated MM6 cells. HIV-1 is dependent upon cellular co-factors to mediate its replication cycle in CD4+ T cells and macrophages, the two major cell types infected by the virus in vivo. One critical co-factor is Cyclin T1, a subunit of a general RNA polymerase II e...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-10234 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse 3T3 cells transduced with cyclin D1 splice variants cyclin D1a and D1b
Cyclin D1 is an important cell cycle regulator but in cancer its overexpression also increases cellular migration mediated by p27KIP1 stabilization and RhoA inhibition. Recently, a common polymorphism at the exon 4-intron 4 boundary of the human cyclin D1 gene within a splice donor region was associ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9161 | biostudies-arrayexpress
TranscriptomicsComparison of Normal Prostate Fibroblasts Overexpressing Cyclin D1 and Carcinoma Associated Fibroblasts
The cyclin D1 oncogene encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the Rb protein and promotes progression through G1 to S phase of the cell cycle. Several prostate cancer cell lines and a subset of primary prostate cancer samples have increased cyclin D1 prote...
ORGANISM(S): Homo sapiens 
2007-08-31 | E-GEOD-6936 | biostudies-arrayexpress
GenomicsCyclin D1 ChIP-seq in H9 undifferentiated human pluripotent stem cells
H9 human pluripotent stem cells were grown in chemically defined media with Activin A and FGF2. Four 10cm plates with 70% confluency were used per sample. Cells were cross-linked by adding a final concentration of 1% PFA into culture media and incubated for 10 min at RT for Cyclin D1 ChIP. ChIP-seq ...
ORGANISM(S): Homo sapiens 
2016-02-01 | E-MTAB-3807 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MM6 cells response to cyclin T1
This SuperSeries is composed of the following subset Series:; GSE10232: CTDG in PMA-activated Jurkat cells; GSE10233: CTDG in PMA-activated MM6 cells; GSE10234: CTDG in LPS-activated MM6 cells; GSE10737: CTDG in non-activated Jurkat cells; GSE10738: CTDG in non-activated MM6 cells; GSE10739: LPS and...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-11462 | biostudies-arrayexpress
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