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MetabolomicsCYP51A1-mediated alkaliptosis resistance is a targetable vulnerability in pancreatic cancer

Alkaliptosis, a pH-dependent form of regulated cell death characterized by impaired lysosomal function and lethal alkalinization, holds promise as a target for cancer therapy. Here, we utilize mass spectrometry-based drug target, transcriptomic screens and lipid metabolomics to explore the metabo...

2025-02-28 | MTBLS9283 | MetaboLights
MetabolomicsCYP51A1-mediated alkaliptosis resistance is a targetable vulnerability in pancreatic cancer

Alkaliptosis, a pH-dependent form of regulated cell death characterized by impaired lysosomal function and lethal alkalinization, holds promise as a target for cancer therapy. Here, we utilize mass spectrometry-based drug target, transcriptomic screens, and lipid metabolomics to explore the metab...

2025-02-28 | MTBLS9288 | MetaboLights
UnknownTopology surveillance of the lanosterol demethylase CYP51A1 by signal peptide peptidase.
Not available
S-EPMC11827857 | biostudies-literature
UnknownCYP51A1 drives resistance to pH-dependent cell death in pancreatic cancer.
Not available
S-EPMC11889236 | biostudies-literature
UnknownHuman Lanosterol 14-Alpha Demethylase (CYP51A1) Is a Putative Target for Natural Flavonoid Luteolin 7,3'-Disulfate.
Not available
S-EPMC8070018 | biostudies-literature
UnknownEvaluation of Selected CYP51A1 Polymorphisms in View of Interactions with Substrate and Redox Partner.
Not available
S-EPMC5492350 | biostudies-literature
UnknownNitric oxide stimulates cellular degradation of human CYP51A1, the highly conserved lanosterol 14α-demethylase.
Not available
S-EPMC5972552 | biostudies-literature
UnknownPolymorphisms of CYP51A1 from cholesterol synthesis: associations with birth weight and maternal lipid levels and impact on CYP51 protein structure.
Not available
S-EPMC3866192 | biostudies-literature
UnknownAmino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents.
Not available
S-EPMC105395 | biostudies-literature
TranscriptomicsLiver transcriptome study in lambs
Feeding animals with either concentrates or alfalfa grazing has been proven to reduce the oxidative process that occurs in meat products. Indoor-kept lambs were fed a standard concentrate (n=7, C) before slaughtering all animals at 22–24 kg of live weight. Simultaneously, 7 unweaned lambs grazed in ...
ORGANISM(S): Ovis aries 
2019-02-05 | GSE125661 | GEO
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