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UnknownInhibition of mitochondrial translation suppresses glioblastoma stem cell growth.
Glioblastoma stem cells (GSCs) resist current glioblastoma (GBM) therapies. GSCs rely highly on oxidative phosphorylation (OXPHOS), whose function requires mitochondrial translation. Here we explore the therapeutic potential of targeting mitochondrial translation and report the results of high-conte...
S-EPMC8097689 | biostudies-literature
UnknownReliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening.
Brain organoids offer unprecedented insights into brain development and disease modeling and hold promise for drug screening. Significant hindrances, however, are morphological and cellular heterogeneity, inter-organoid size differences, cellular stress, and poor reproducibility. Here, we describe a...
S-EPMC11659410 | biostudies-literature
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