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TranscriptomicsGenome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells
Recent studies have demonstrated that the Ten-eleven translocation (Tet) family proteins can enzymatically convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). While 5mC has been studied extensively, little is known about the distribution and function of 5hmC. Here we present a genome...
ORGANISM(S): Mus musculus 
2011-03-30 | E-GEOD-27613 | biostudies-arrayexpress
GenomicsGenome-wide analysis reveals TET- and TDG-mediated 5-methylcytosine oxidation dynamics [MeDIP-Seq]
Ten-eleven translocation (Tet) family of DNA dioxygenases converts 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5- carboxylcytosine (5caC) through iterative oxidation reactions. While 5mC and 5hmC are relatively abundant, 5fC and 5caC are at very low levels...
ORGANISM(S): Mus musculus 
2013-04-18 | E-GEOD-46111 | biostudies-arrayexpress
TranscriptomicsDual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells (ChIP-chip and MeDIP-chip)
Epigenetic modification of the mammalian genome by DNA methylation (5-methylcytosine) has a profound impact on chromatin structure, gene expression and maintenance of cellular identity. Recent demonstration that members of the Ten-eleven translocation (Tet) family proteins can convert 5-methylcytosi...
ORGANISM(S): Mus musculus 
2011-03-30 | E-GEOD-26827 | biostudies-arrayexpress
GenomicsDual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells (ChIP-Seq)
Epigenetic modification of the mammalian genome by DNA methylation (5-methylcytosine) has a profound impact on chromatin structure, gene expression and maintenance of cellular identity. Recent demonstration that members of the Ten-eleven translocation (Tet) family proteins can convert 5-methylcytosi...
ORGANISM(S): Mus musculus 
2011-03-30 | E-GEOD-26832 | biostudies-arrayexpress
TranscriptomicsDual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells (mRNA)
Epigenetic modification of the mammalian genome by DNA methylation (5-methylcytosine) has a profound impact on chromatin structure, gene expression and maintenance of cellular identity. Recent demonstration that members of the Ten-eleven translocation (Tet) family proteins can convert 5-methylcytosi...
ORGANISM(S): Mus musculus 
2011-03-30 | E-GEOD-26830 | biostudies-arrayexpress
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