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ProteomicsThe Carnosine–HNE Michael Adduct as a Redox-Active Species Associated with Nrf2-Dependent Antioxidant and An-ti-Inflammatory Responses
Carnosine (CAR), an endogenous histidine-containing dipeptide, exhibits antioxidant and anti-inflammatory activity in various experimental models; however, its molecular mechanism of action remains poorly understood. Here, we demonstrate that the Michael adduct between CAR and 4-hydroxy-2-nonenal (H...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-06 | PXD075159 | Pride
Carnosine  4-hydroxy-2-nonenal (hne)  nrf2 activation  nf-κb  anti-inflammatory  anti-oxidant. 
ProteomicsEXPLORING THE ANTI-INFLAMMATORY POTENTIAL OF THINNED APPLE POLYPHENOLS: MECHANISTIC PROTEOMICS INSIGHTS INTO DNBS-INDUCED COLITIS MODEL IN MICE
Ulcerative colitis (UC) is a multifactorial inflammatory bowel disease (IBD) with increasing incidence worldwide. Current treatments, such as NSAIDs and corticosteroids, provide partial symptom relief but are associated to significant side effects. This highlights the need for novel therapies with f...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD056914 | Pride
Nf-κb  nrf2  anti-inflammatory  anti-oxidant  polyphenols  proteomics  thinned apples 
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