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GenomicsFANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis
Fanconi Anemia (FA) is a rare genetic disorder characterized by an increased susceptibility to squamous cell cancers. Fifteen FA genes are known, and the encoded proteins cooperate in a common DNA repair pathway. A critical step is the monoubiquitination of the FANCD2 protein, and cells from most...
ORGANISM(S): Homo sapiens 
2013-06-27 | E-GEOD-46902 | biostudies-arrayexpress
UnknownA DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapy.
Not available
S-EPMC3341307 | biostudies-literature
UnknownUSP9X inhibition promotes radiation-induced apoptosis in non-small cell lung cancer cells expressing mid-to-high MCL1.
Not available
S-EPMC4622494 | biostudies-literature
UnknownAlterations in ileal transcriptomics during an intestinal barrier challenge in lactating Holstein cows fed a Saccharomyces cerevisiae fermentation product identify potential regulatory processes.
Not available
S-EPMC10576520 | biostudies-literature
UnknownCytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells.
Not available
S-EPMC2964984 | biostudies-literature
UnknownFANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair.
Not available
S-EPMC4939765 | biostudies-literature
UnknownHepatic transcript profiling in beef cattle: Effects of feeding endophyte-infected tall fescue seeds.
Not available
S-EPMC11280227 | biostudies-literature
TranscriptomicsTranscription profiling by array of Fanconi Anemia patient (FANCA) EBV cell line transduced with control shRNA or a shRNA targeting p53 and treated with a Mitomycin C (MMC) pulse
Time point (H0, H24, H72) expression data from an EBV cell line obtained from a Fanconi Anemia patient (FANCA) transduced with a control shRNA (sh Ctrl) (n=3) or a shRNA targeting p53 (sh p53) (n=3) and treated with a brief MMC pulse.
ORGANISM(S): Homo sapiens 
2012-10-23 | E-MTAB-1099 | biostudies-arrayexpress
UnknownThe USP1/UAF1 complex promotes double-strand break repair through homologous recombination.
Not available
S-EPMC3133424 | biostudies-literature
UnknownClear cell ovarian cancers with microsatellite instability: A unique subset of ovarian cancers with increased tumor-infiltrating lymphocytes and PD-1/PD-L1 expression.
Not available
S-EPMC5353914 | biostudies-literature
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