Sort   by:  
 Page size 
GenomicsFANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis
Fanconi Anemia (FA) is a rare genetic disorder characterized by an increased susceptibility to squamous cell cancers. Fifteen FA genes are known, and the encoded proteins cooperate in a common DNA repair pathway. A critical step is the monoubiquitination of the FANCD2 protein, and cells from most...
ORGANISM(S): Homo sapiens 
2013-06-27 | E-GEOD-46902 | biostudies-arrayexpress
ProteomicsCHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair
The CHAMP1 complex, a little-known but highly conserved protein complex consisting of CHAMP1, POGZ, and HP1, is enriched in heterochromatin though its cellular function in these regions of the genome remain unknown. Here we show that the CHAMP complex promotes heterochromatin assembly at multiple ch...
ORGANISM(S): Hordeum vulgare (Barley) 
2025-05-07 | PXD055109 | Pride
Human 
ProteomicsCooperation of the NEIL3 and Fanconi Anemia/BRCA Pathways in Interstrand Crosslink Repair
The NEIL3 DNA glycosylase is a base excision repair enzyme that excises bulky base lesions from DNA. Although NEIL3 has been shown to unhook interstrand crosslinks (ICL) in Xenopus extracts, how NEIL3 participants in ICL repair in human cells and its corporation with the canonical Fanconi anemia (FA...
ORGANISM(S): Homo sapiens (Human) 
2020-01-20 | PXD016256 | Pride
Neil3 Psoralen interstrand crosslink Fanconi anemia 
GenomicsThe Splicing Factor CCAR1 Regulates the Fanconi Anemia/BRCA Pathway
The Splicing Factor CCAR1 Regulates the Fanconi Anemia/BRCA Pathway
PRJNA1014549 | ENA
GenomicsThe effects of expression of the EWS-FLI1 oncoprotein on alternative splicing
The effects of expression of the EWS-FLI1 oncoprotein on alternative splicing
PRJNA1416889 | ENA
GenomicsCHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress
CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress
PRJNA664943 | ENA
GenomicsPARG inhibitor sensitivity correlates with accumulation of single strand DNA gaps in preclinical models of ovarian cancer
PARG inhibitor sensitivity correlates with accumulation of single strand DNA gaps in preclinical models of ovarian cancer
PRJNA1126286 | ENA
GenomicDNA Repair Profiling of HGSC Organoids

In this study, 34 ovarian tumor organoids generated from 23 patients underwent paired DNA damage repair defect functional analyses and whole exome sequencing analysis to compare genetic mutational status to DNA repair functional capacity. 22 of the patients had high grade serous cancer and 1 of t...

phs001685 | dbGaP
GenomicsBRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair
Brca1 is required for DNA repair by homologous recombination (HR) and normal embryonic development. Here we report that deletion of the DNA damage responsefactor 53BP1 overcomes embryonic lethality in Brca1-nullizygous mice, and rescues HR deficiency, as measured by hypersensitivity to PARP (polyADP...
ORGANISM(S): Mus musculus 
2012-09-30 | E-GEOD-35698 | biostudies-arrayexpress
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
Sort   by:  
 Page size