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UnknownCortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group.
Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies have been inconsistent. To address this, we performed the largest study to date of cortical gray ma...
S-EPMC5668195 | biostudies-literature
UnknownProgression of HPV infection to detectable cervical lesions or clearance in adult women: Analysis of the control arm of the VIVIANE study.
The control arm of the phase III VIVIANE (Human PapillomaVIrus: Vaccine Immunogenicity ANd Efficacy; NCT00294047) study in women >25 years was studied to assess risk of progression from cervical HPV infection to detectable cervical intraepithelial neoplasia (CIN). The risk of detecting CIN associate...
S-EPMC4787275 | biostudies-literature
UnknownRefining the diagnosis of gestational diabetes mellitus: a systematic review and meta-analysis.

Background

Perinatal outcomes vary for women with gestational diabetes mellitus (GDM). The precise factors beyond glycemic status that may refine GDM diagnosis remain unclear. We conducted a systematic review and meta-analysis of potential precision markers for GDM.

Methods

Systematic...
S-EPMC10728189 | biostudies-literature
UnknownReaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a new low molecular weight inhibitor class with drug-like physi...
S-EPMC10402266 | biostudies-literature
UnknownReaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a new low molecular weight inhibitor class with drug-like physi...
S-EPMC10831071 | biostudies-literature
UnknownGlobal disparities in SARS-CoV-2 genomic surveillance.
Genomic sequencing is essential to track the evolution and spread of SARS-CoV-2, optimize molecular tests, treatments, vaccines, and guide public health responses. To investigate the global SARS-CoV-2 genomic surveillance, we used sequences shared via GISAID to estimate the impact of sequencing inte...
S-EPMC9667854 | biostudies-literature
UnknownResuscitation fluid practices in Brazilian intensive care units: a secondary analysis of Fluid-TRIPS.

Objective

To describe fluid resuscitation practices in Brazilian intensive care units and to compare them with those of other countries participating in the Fluid-TRIPS.

Methods

This was a prospective, international, cross-sectional, observational study in a convenience sample of inte...
S-EPMC8275089 | biostudies-literature
UnknownExtreme drought impacts have been underestimated in grasslands and shrublands globally.
Climate change is increasing the frequency and severity of short-term (~1 y) drought events-the most common duration of drought-globally. Yet the impact of this intensification of drought on ecosystem functioning remains poorly resolved. This is due in part to the widely disparate approaches ecologi...
S-EPMC10823251 | biostudies-literature
UnknownResponses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial.

Background

In a randomized, placebo-controlled, clinical trial, bamlanivimab, a SARS-CoV-2-neutralizing monoclonal antibody, given in combination with remdesivir, did not improve outcomes among hospitalized patients with COVID-19 based on an early futility assessment.

Objective

To eva...
S-EPMC9334931 | biostudies-literature
UnknownBioTIME: A database of biodiversity time series for the Anthropocene.

Motivation

The BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a c...
S-EPMC6099392 | biostudies-literature
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