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ProteomicsAmyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity
Here, we combine cryo-electron tomography, proteomics and cell biology studies to investigate the effects of protein aggregates in primary neurons. We use artificial amyloid-like β-sheet proteins (β proteins) to focus on the gain-of-function aspect of aggregation. These proteins form fibrillar aggre...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-20 | PXD029689 | Pride
Neurons Toxic proteins Protein aggregates Neurodegeneration 
UnknownGenetic Diversity of Plasmodium vivax Cysteine-Rich Protective Antigen (PvCyRPA) in Field Isolates from Five Different Areas of the Brazilian Amazon.
Not available
S-EPMC8623135 | biostudies-literature
UnknownCracking the code: a scoping review to unite disciplines in tackling legal issues in health artificial intelligence.
Not available
S-EPMC11987151 | biostudies-literature
UnknownMagnetic Nanocarriers with ICPTES- and GPTMS-Functionalized Quaternary Chitosan for pH-Responsive Doxorubicin Release.
Not available
S-EPMC12839120 | biostudies-literature
UnknownResveratrol-Loaded Polydimethylsiloxane-Silica Hybrid Materials: Synthesis, Characterization, and Antitumoral Activity.
Not available
S-EPMC11013690 | biostudies-literature
TranscriptomicsTranscription profiling of mouse C2C12 myotubes treated overnight with 500 uM palmitate or 1% bovine serum albumin control to identify mediators of obesity-linked reductions in PGC-1
To identify mediators of obesity-linked reductions in PGC-1, we tested the effects of cellular nutrients in C2C12 myotubes. While overnight exposure to high insulin, glucose, glucosamine, or amino acids had no effect, saturated fatty acids (FA) potently reduced PGC-1a and b mRNA expression. Exper...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6766 | biostudies-arrayexpress
UnknownCarbohydrates from Pseudomonas aeruginosa biofilms interact with immune C-type lectins and interfere with their receptor function.
Not available
S-EPMC8655052 | biostudies-literature
UnknownEffect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial.
Not available
S-EPMC12124691 | biostudies-literature
ProteomicsSARS-CoV-2 infects brain astrocytes of COVID-19 patients and impairs neuronal viability
COVID-19 patients may exhibit neuropsychiatric and neurological symptoms. We found that anxiety and cognitive impairment are manifested by 28-56% of SARS-CoV-2-infected individuals with mild respiratory symptoms and are associated with altered cerebral cortical thickness. Using an independent cohort...
ORGANISM(S): Homo sapiens (Human) 
2022-09-01 | PXD023781 | Pride
Covid-19 Astrocytes Proteomics Sars-cov2 
UnknownSynthetic Antigens Derived from Plasmodium falciparum Sporozoite, Liver, and Blood Stages: Naturally Acquired Immune Response and Human Leukocyte Antigen Associations in Individuals Living in a Brazilian Endemic Area.
Not available
S-EPMC5817778 | biostudies-literature
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