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TranscriptomicsAdipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity
This SuperSeries is composed of the following subset Series: GSE25401: Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity [gene expression] GSE25470: Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity [miRNA data] GSE25910: Adipose Tissue MicroRNAs as ...
ORGANISM(S): Homo sapiens 
2012-08-12 | E-GEOD-25402 | biostudies-arrayexpress
TranscriptomicsThe epigenetic signature of subcutaneous fat cells is linked to altered expression of genes implicated in lipid metabolism in obese women
Background Obesity is associated with changes in fat cell gene expression and metabolism. What drives these changes is not well understood. We aimed to explore fat cell epigenetics, i.e., DNA methylation, as one mediator of gene regulation, in obese women. The global DNA methylome for abdominal subc...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-GEOD-67024 | biostudies-arrayexpress
TranscriptomicsA healthy Nordic diet has a beneficial influence on the expression of genes involved in inflammation in subcutaneous adipose tissue
In a randomized controlled dietary intervention study we compared an isocaloric Healthy Nordic diet with the average Nordic diet for influence on abdominal subcutaneous adipose tisse gene expression. We studied obese adults with features of the metabolic syndrom, n=56. There was no significant diffe...
ORGANISM(S): Homo sapiens 
2015-01-26 | E-GEOD-56716 | biostudies-arrayexpress
TranscriptomicsThe fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes
Background/Objectives: Obese subjects have increased number of enlarged fat cells which are reduced in size but not number in post-obesity. We performed DNA methylation profiling in fat cells with the aim of identifying differentially methylated DNA sites (DMS) linked to adipose hyperplasia (many sm...
ORGANISM(S): Homo sapiens 
2015-05-06 | E-GEOD-58622 | biostudies-arrayexpress
TranscriptomicsRole of milk fat globule membrane (MFGM) in modulating gene expression in humans
The aim of this study was to investigate if milk fat globule membrane (MFGM) enclosing the dairy fat influence peripheral blood mononuclear cells (PBMC) gene expression. This study was a 8-week single-blind, randomized, controlled isocaloric trial with two parallel groups including overweight (mean ...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-60148 | biostudies-arrayexpress
TranscriptomicsInfluence of dietary fatty acid composition on white adipose tissue gene expression in humans
In a randomized controlled dietary intervention study, we compared a diet enriched in polyunsaturated fatty acids (PUFA) with a diet enriched in saturated fatty acids (SFA) for influence on abdominal subcutaneous adipose tissue gene expression. We studied young lean adults; 11 women and 25 men. Ther...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-43642 | biostudies-arrayexpress
TranscriptomicsADIPOSE TISSUE PATHWAYS INVOLVED IN WEIGHT LOSS OF CANCER CACHEXIA
The regulatory gene pathways underlying the loss of adipose tissue in cancer cachexia are unknown and were explored using pangenomic transcriptome profiling. Gene expression profiles (Human Gene 1.0 ST) of abdominal subcutaneous adipose tissue were studied in gastrointestinal cancer patients with (N...
ORGANISM(S): Homo sapiens 
2010-04-10 | E-GEOD-20571 | biostudies-arrayexpress
TranscriptomicsAdipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity [gene expression]
We used an unbiased systems biology approach to study the regulation of gene expression in human adipose tissue focusing on inflammation. We show that microRNAs play a major role as regulators of CCL2 production in obesity. Abdominal subcutaneous adipose needle biopsies were obtained from women (n=5...
ORGANISM(S): Homo sapiens 
2012-08-12 | E-GEOD-25401 | biostudies-arrayexpress
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