Sort   by:  
 Page size 
TranscriptomicsMicroRNA-520c-3p targets eIF4GII and acts as a tumor suppressor in diffuse large B cell lymphoma
Deregulation of the translational machinery is emerging as a critical contributor to lymphomagenesis. Various miRNA alterations have been identified in lymphoma, but their role in disrupting the cap-dependent translation regulation complex remains poorly understood. Here, we demonstrate the translat...
ORGANISM(S): Homo sapiens 
2014-03-19 | E-GEOD-40489 | biostudies-arrayexpress
TranscriptomicsDistinct inhibitory effects on mTOR signaling by ethanol and INK128 in diffuse large B-cell lymphoma
The mechanistic target of rapamycin, (mTOR) kinase plays a pivotal role in controlling critical cellular growth and survival pathways, and its aberrant induction is implicated in cancer pathogenesis. Therefore, suppression of active mTOR signaling has been of great interest to researchers; several m...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-62790 | biostudies-arrayexpress
TranscriptomicsIdentification of transformation-related pathways in a breast epithelial cell model using a ribonomics approach.
Employing MCT-1 oncogene mediated transformation of immortalized breast epithelial MCF10A cells; we characterized the largely reciprocal association of these two RBPs with target mRNAs and their influence on protein expression vis-à-vis cellular transformation. Using a ribonomics approach, we ident...
ORGANISM(S): Homo sapiens 
2008-07-29 | E-GEOD-12215 | biostudies-arrayexpress
TranscriptomicsATM regulates a DNA damage response post-transcriptional RNA operon in lymphocytes
Maintenance of genomic stability depends on the DNA damage response (DDR), a biological barrier in early stages of cancer development. Failure of this response results in genomic instability and high predisposition toward lymphoma, as seen in patients with ataxia-telangiectasia mutated (ATM) dysfunc...
ORGANISM(S): Homo sapiens 
2011-01-05 | E-GEOD-25848 | biostudies-arrayexpress
Sort   by:  
 Page size