Proteome data derive from three different types of cells （uninfected gADSCs, gADSCs infected with the empty lentiviral vector, and gADSCs infected with the miR-204-5p lentiviral vector).
Chen et al. discovered a highly potent and selective MLKL-targeted PROTAC C116 that effectively induces MLKL degradation and promotes parthanatos in HCC cells. More significantly, C116 was able to induce in vivo MLKL degradation and exerts anti-tumor activities in an orthotopic HCC tumor model, posi...
