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TranscriptomicsGene Expression Profiles of MYC+ and MYC- mouse Germinal Center B cells
Germinal centers (GC) arise within B cell follicles upon antigenic challenge. In the dark zones (DZ) of GCs, B cells proliferate and hypermutate their immunoglobulin genes, and mutants with increased affinity are positively selected in the light zone (LZ) to either differentiate into plasma and memo...
ORGANISM(S): Mus musculus 
2012-09-24 | E-GEOD-38304 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of normal mature B cells
miRNA profiling has been performed on normal mature B cells at different stages of differentiation (naive, germinal center and memory). The main goal is to identify miRNA signatures associated with differentiation stages of normal B cells. Keywords: miRNA, normal mature B cells Cells were isolated...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-15144 | biostudies-arrayexpress
GenomicsChIPseq analyses in germinal center B cells
Germinal center B cells were isolated from human tonsil tissue and crosslinked. ChIP was performed on two distinct pools of germinal center cells, each obtained from 3-5 donors. The experiment includes two biological replicates (germinal center cell pools from different donors). ChIP was performed o...
ORGANISM(S): Homo sapiens 
2015-12-04 | E-GEOD-68349 | biostudies-arrayexpress
TranscriptomicsSmall-RNA expression in normal and malignant mature B cells
Small-RNA profiles were generated for normal mature germinal center (GC) B cells and GC-derived lymphomas. Normal and tumor samples are derived from different donors.
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-56354 | biostudies-arrayexpress
TranscriptomicsExpression profiles of murine FOXO1+/+ and FOXO1-null GC B cells
The pathways regulating the formation of the germinal center (GC) dark- (DZ) and light- (LZ) zones are unknown. We show that FOXO1 expression is restricted to the GC DZ and is required for DZ formation, since its absence in mice leads to the complete loss of DZ gene programs and the formation of LZ-...
ORGANISM(S): Mus musculus 
2015-12-04 | E-GEOD-69216 | biostudies-arrayexpress
TranscriptomicsmiR-28 expression in the Burkitt lymphoma cell line P3HR1
Burkitt lymphoma (BL) is a highly aggressive B cell non-Hodgkin lymphoma (B-NHL), which originates from germinal center (GC) B cells and harbors translocations deregulating the MYC oncogene. A comparative analysis of microRNAs (miRNAs) expressed in normal and malignant GC B cells identified miR-28 a...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-56268 | biostudies-arrayexpress
GenomicsHigh density copy number analysis and whole exome sequencing of diffuse large B-cell lymphoma

Diffuse Large B-cell Lymphoma (DLBCL) represents the most common form of B-cell non-Hodgkin Lymphoma (B-NHL), accounting for ~30% of the de-novo diagnoses and also arising as a frequent clinical evolution of Follicular Lymphoma (FL). The molecular pathogenesis of DLBCL is associated with multip...

phs000328.v1.p1 | EGA
GenomicsHigh density copy number analysis and whole exome sequencing of chronic lymphocytic leukemia

The pathogenesis of chronic lymphocytic leukemia (CLL), the most common leukemia in adults, is still largely unknown since the full spectrum of genetic lesions that are present in the CLL genome, and therefore the number and identity of dysregulated cellular pathways, have not been iden...

phs000364.v1.p1 | EGA
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