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TranscriptomicsGene expression profile of mock and FLT3-ITD-expressing K562 cells.
We used whole genome microarray expression profiling as a discovery platform to identify genes regulated by FLT3-ITD activity. Viral particles with pMY-puro, pMY-puro-FLT3-ITD-1 or pMY-puro-FLT3-ITD-2, were generated using PLAT-gp packaging cells and infected to K562 cells. The vector-transduced cel...
ORGANISM(S): Homo sapiens 
2015-09-09 | E-GEOD-64330 | biostudies-arrayexpress
TranscriptomicsThe induced APL cells generated by the transplantation of PML-RARA-transduced human CD34+ hematopoietic cells into immunodeficient mice
A humanized in vivo APL model has been established utilizing the retroviral transduction of PML-RARA into human CD34+ hematopoietic cells and the transplantation of these cells into immunodeficient mice. The resultant leukemia recapitulated human APL phenotypically, and was clustered in the same cat...
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-49344 | biostudies-arrayexpress
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