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MetabolomicsNPC1 regulates the distribution of phosphatidylinositol 4 kinases at Golgi and Lysosome membranes
Cholesterol and phosphoinositides (PI) are two critically important lipids that are found in cellular membranes and dysregulated in many disorders. Therefore, uncovering molecular pathways connecting these essential lipids may offer new therapeutic insights. We report that loss of function of lysoso...
2021-09-15 | MTBLS2612 | MetaboLights
MetabolomicsLarge neutral amino acid levels tune perinatal neuronal excitability and survival
Surprisingly little is known about the critical metabolic changes that neural cells have to undergo during development and how even mild, temporary shifts in this program can influence brain circuitries and behavior. Inspired by the discovery that mutations in SLC7A5, a transporter of metabolically-...
2023-03-28 | MTBLS6578 | MetaboLights
GenomicsTransposon sequencing to identify random insertions of lox sites in Mycoplasma pneumoniae
This dataset was used to assess the random insertion by tranposases of lox sites in Mycoplasma pneumoniae. This is part of the protocol LoxTnSeq, a new methodology to generate and catalogue libraries of genome reduction mutants. LoxTnSeq combines random integration of Lox sites by transposon mutagen...
ORGANISM(S): Mycoplasma pneumoniae 
2021-08-18 | E-MTAB-9590 | biostudies-arrayexpress
TranscriptomicsDNA sequencing to validate random deletions in Mycoplasma pneumoniae
We present LoxTnSeq, a new methodology to generate and catalogue libraries of genome reduction mutants. LoxTnSeq combines random integration of Lox sites by transposon mutagenesis, and the generation of mutants via cre recombinase, catalogued via deep-sequencing. When LoxTnSeq was applied to the nat...
ORGANISM(S): Mycoplasma pneumoniae 
2021-08-18 | E-MTAB-9582 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of RET finger protein/ Tripartite protein in human osteosarcoma cell lines and analysis of Retinoblastoma protein dependent transcriptional changes
Analysis of Retinoblastoma protein (Rb) (Hs.408528) dependent transcriptional changes following siRNA mediated ablation of the RET finger protein/ Tripartite protein (RFP/TRIM27) (Hs.440382). Common reference design, two biological replicates with two technical replicates each.
ORGANISM(S): Homo sapiens 
2005-06-02 | E-MEXP-278 | biostudies-arrayexpress
UnknownRandomized, phase III trial of first-line figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin alone in patients with advanced non-small-cell lung cancer.
Not available
S-EPMC4067944 | biostudies-literature
UnknownAdo-Trastuzumab Emtansine for Patients With HER2-Mutant Lung Cancers: Results From a Phase II Basket Trial.
Not available
S-EPMC6366814 | biostudies-literature
UnknownRandomized controlled trial of a cognitive-behavioral therapy plus hypnosis intervention to control fatigue in patients undergoing radiotherapy for breast cancer.
Not available
S-EPMC3918539 | biostudies-literature
MetabolomicsA data integration multi-omics approach to study calorie restriction-induced changes in insulin sensitivity
The mechanisms responsible for weight loss-induced improvement in insulin sensitivity are partially understood. Greater insight can now be achieved through deep phenotyping and data integration. Here, we used an integrative approach to investigate associations between changes in insulin sensitivity ...
2021-02-11 | MTBLS653 | MetaboLights
TranscriptomicsGenotyping of 4 female and 4 male Caucasians
Genotyping of eight human individuals which was used alongside RNA-seq data of the same individuals (SRA062051)
ORGANISM(S): Homo sapiens 
2013-11-26 | E-MTAB-1450 | biostudies-arrayexpress
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