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TranscriptomicsDiverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells (Affymetrix)
The effects of diverse stresses on promoter selectivity and transcription regulation by the tumor suppressor p53 are poorly understood. We have taken a comprehensive approach to characterizing the human p53 network that includes p53 levels, binding, expression and chromatin changes under diverse str...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-46493 | biostudies-arrayexpress
MetabolomicsTargeted metabolomic analysis in hepatic extracts, serum, and urine of female mice gavaged with TCDD every 4 days for 28 days
TCDD is an environmental contaminant that elicits a number of hepatic effects including fat accumulation, inflammation, and fibrosis that can progress to hepatocellular carcinoma. RNA-Seq and targeted metabolomics were integrated with complementary dioxin response element (DRE) location and aryl hyd...
2017-02-02 | MTBLS225 | MetaboLights
ProteomicsComprehensive respiratory phenomics across multiple models of mitochondrial protein hyperacylation reveals a paradoxically marginal impact on bioenergetics
Acyl CoA metabolites derived from catabolism of carbon fuels can react with lysine residues of mitochondrial proteins, giving rise to a large family of post-translation modifications (PTMs). Mass spectrometry-based detection of thousands of acyl-PTMs scattered throughout the proteome has established...
ORGANISM(S): Mus Musculus (mouse) 
2019-02-07 | PXD011375 | JPOST Repository
TranscriptomicsIntragraft molecular pathways associated with tolerance induction in renal transplantation
Complications associated with immunosuppression, specifically nephrotoxicity and infection risk, significantly affect graft and patient survival after kidney transplantation. We previously showed that tolerance could be induced and full donor chimerism, as well as immunosuppression withdrawal, was o...
ORGANISM(S): Homo sapiens 
2018-05-07 | E-GEOD-106675 | biostudies-arrayexpress
GenomicCholesterol and Pharmacogenetics (CAP) Study

The Cholesterol and Pharmacogenetics Study was a 6-week open label, non-randomized study of 40mg/day simvastatin treatment in 335 African-American and 609 Caucasian (944 total) men and women. Plasma lipids and lipoproteins were measured on two occasions prior to treatment and at 4 and 6 weeks of ...

phs000481 | dbGaP
UnknownSex differences in atrial fibrillation in India: Insights from the Kerala-AF registry.
Not available
S-EPMC11730713 | biostudies-literature
Genomicsena-DATASET-ICR-PTGT-28-07-2015-16:51:33:172-264 - samples
Anaplastic oligodendrogliomas (AOs) are rare primary brain tumors which are generally incurable, with heterogeneous prognosis and few treatment targets identified. Most oligodendrogliomas have chromosome 1p/19q co-deletion and IDH mutation. We analyzed 51 AOs by whole-exome sequencing, identifying p...
EGAD00001001452 | EGA
GenomicsAnaplastic oligodendroglioma exome and RNA sequencing data
Anaplastic oligodendrogliomas (AOs) are rare primary brain tumors which are generally incurable, with heterogeneous prognosis and few treatment targets identified. Most oligodendrogliomas have chromosome 1p/19q co-deletion and IDH mutation. We analyzed 51 AOs by whole-exome sequencing, identifying p...
EGAS00001001209 | EGA
UnknownPhenotypes of South Asian patients with atrial fibrillation and holistic integrated care management: cluster analysis of data from KERALA-AF Registry.
Not available
S-EPMC11609390 | biostudies-literature
ProteomicsPrioritisation, Identification, and Quantification of Emerging Contaminants in Recycled Textiles Using Non-Targeted and Suspect Screening Workflows by LC-ESI-HRMS
Recycled textile samples obtained in Sweden, 2021. Multi-residue extraction method used. Top-5 DDA + Inclusion List employed for MS2 acquisition. mzML files converted from raw data (ProteoWizard::msConvert).
ORGANISM(S): Na 
2024-06-29 | MSV000095185 | MassIVE
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