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TranscriptomicsNutrigenomics in honey bees: the impact of pollen nutrients on bee health
We studied the molecular mechanisms underlying the impact of pollen nutrients on honey bee (Apis mellifera) health and how those nutrients improve resistance to parasites. Using digital gene expression, we determined the changes in gene expression induced by pollen intake in worker bees parasitized ...
ORGANISM(S): Apis mellifera 
2011-11-06 | E-GEOD-25161 | biostudies-arrayexpress
GenomicsUnraveling cell type–specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs
Short nascent strands purification coupled to next-generation sequencing allowed us to identify replication origins on human genome in an extensive way, by mapping replication origins in 4 different cell types, IMR-90 fibroblasts, hESC H9 cells, iPSC Th Cl-4 cells and HeLa cells. We demonstrated the...
ORGANISM(S): Homo sapiens 
2012-07-01 | E-GEOD-37757 | biostudies-arrayexpress
TranscriptomicsA systems-level approach to parental genomic imprinting: the imprinted gene network includes extracellular matrix genes and regulates cell cycle exit and differentiation
We used the 3T3-L1 preadipocyte cell line (Green and Kehinde. Cell 5:19-25, 1974; ATCC CL-173), in which adipogenic differentiation is experimentally induced when quiescent 3T3-L1 cells are incubated with serum and IDX (insulin, dexamethasone, isobutylmethylxanthine). Following IDX addition, the cel...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-50612 | biostudies-arrayexpress
Transcriptomicsbeta-arrestin-2 deficiency effect on intestinal tumorigenesis in Apc-mutated mice
Amoung their pleiotropic functions, a role was recently assigned for b-arrestin scaffold proteins in tumor growth, angiogenesis and invasion. In order to elucidate the roles of b-arrestins in tumour developement in intestinal epithelium initiated by Apc mutation, we determined the effects of b-arres...
ORGANISM(S): Mus musculus 
2012-01-20 | E-GEOD-24575 | biostudies-arrayexpress
TranscriptomicsThe 'PUCE CAFÉ' project: A genome-wide 15K coffee microarray, a new tool to discover candidate genes correlated to quality traits
Background: Understanding the genetic elements that contribute to key aspects of coffee biology will impact future agronomical improvements for this economically important tree. The past years, EST collections were generated in Coffee, opening the possibility to create new tools for functional genom...
ORGANISM(S): Coffea arabica 
2011-11-01 | E-GEOD-24754 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of tumors from ApcD14/+ mice
Amoung their pleiotropic functions, a role was recently assigned for b-arrestin scaffold proteins in tumor growth, angiogenesis and invasion. In order to elucidate the roles of b-arrestins in tumour developement in intestinal epithelium initiated by Apc mutation, we determined the effects of b-arres...
ORGANISM(S): Mus musculus 
2012-01-20 | E-GEOD-24576 | biostudies-arrayexpress
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