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MetabolomicsA neurotoxic cellular stress response linked to dark microglia and toxic lipid secretion

Microglia, the brain’s primary resident immune cells, can assume various phenotypes with diverse functional outcomes on brain homeostasis. In Alzheimer’s disease (AD), where microglia are a leading causal cell type, the identity of microglia subsets that drive neurodegeneration remains unresolved...

2024-12-20 | MTBLS11942 | MetaboLights
MetabolomicsSerine Metabolism Tunes Immune Responses To Promote Oreochromis niloticus Survival upon Edwardsiella tarda Infection
Overactive immune response is a critical factor triggering host death upon bacterial infection. However, the mechanism behind the regulation of excessive immune responses is still largely unknown, and the corresponding control and preventive measures are also to be explored. In this study, we find t...
2021-08-18 | MTBLS2974 | MetaboLights
ProteomicsFragilariopsis Cylindrus dark survival experiment
The sea-ice dwelling diatom Fragilariopsis Cylindrus was cultured for 4 months under dark or light exposed conditions to mimic the effects of Antarctic winter growth conditions. Cells were harvested periodically and LFQ proteomics used to investigate the molecular mechanisms of dark survival.
ORGANISM(S): Fragilariopsis cylindrus 
2019-04-23 | PXD007098 | Pride
Dark survival Sea-ice diatom Quantitative proteomics 
MetabolomicsAcupuncture Synergized With Bortezomib Improves Survival of Multiple Myeloma Mice via Decreasing Metabolic Ornithine
Multiple myeloma (MM) is a hematological malignancy worldwide in urgent need for novel therapeutic strategies. Since Velcade (bortezomib) was approved for the treatment of relapsed/refractory MM in 2003, we have seen considerable improvement in extending MM patient survival. However, most patients a...
2022-02-21 | MTBLS3487 | MetaboLights
ProteomicsSyn6803 Pyk-ox under light and dark
Effect of pyruvate kinase (Sll0587) overexpression under both light and dark conditions.
ORGANISM(S): Cellular Organisms 
2024-10-16 | PXD053484 | JPOST Repository
MetabolomicsLimited survival and impaired hepatic fasting metabolism of glucose, amino acids and lipids in mice with constitutive Rag GTPase signaling
The mechanistic target of rapamycin complex 1 (mTORC1) integrates cellular nutrient signaling and hormonal cues to control metabolism. We have previously shown that constitutive nutrient signaling to mTORC1 by means of genetic activation of RagA (RagAGTP) in mice resulted in a fatal energetic crisis...
2021-05-11 | MTBLS2397 | MetaboLights
TranscriptomicsComparison of the Transcriptional Profiles of Melanocytes from Dark and Light Skinned Individuals under Basal Conditions and Following Ultraviolet-B Irradiation
We analysed the whole-genome transcriptional profile of 6 cell lines of dark melanocytes (DM) and 6 of light melanocytes (LM) at basal conditions and after UVB at different time points (6, 12 and 24h) to investigate the mechanisms by which melanocytes protect human skin from the damaging effects of ...
ORGANISM(S): Homo sapiens 
2015-08-08 | E-GEOD-70280 | biostudies-arrayexpress
TranscriptomicsRNAseq of dark dissected, 3 day old Arabidopsis (col0) seedlings, including cotyledons, apical hooks and hypocotyls
Seedling establishment is a critical developmental transition that contributes to survival in the local environment. While light is the primary cue driving de-etiolation, how abiotic stress shapes early development in darkness remains unclear. We show that salinity induces a photomorphogenic-like re...
ORGANISM(S): Arabidopsis thaliana 
2026-06-23 | E-MTAB-16552 | biostudies-arrayexpress
ProteomicsVibrio campbellii C/N-limitation
Analyses of Vibrio campbellii CAIM519 under C- and N-limited growth conditions, in both light and dark. Peak Lists are diDO-IPTL analyses; Raw files are unlabeled peptide with 2 synthetic proteorhodopsin standard peptides. See Gallagher & Waldbauer (mSystems) for details.
ORGANISM(S): Vibrio Campbellii Caim 519 = Nbrc 15631 (ncbitaxon:1224742) 
2021-03-25 | MSV000087100 | MassIVE
TranscriptomicsLow-power photodynamic therapy induces survival signaling in cultured hilar cholangiocarcinoma cells
Photodynamic therapy (PDT) of solid cancers comprises the administration of a photosensitizer followed by illumination of the photosensitizerreplete tumor with laser light. This induces a state of local oxidative stress, culminating in the destruction of tumor tissue and microvasculature and inducti...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-68292 | biostudies-arrayexpress
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