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The RNA-seq library preparation was performed for H357 CisR Nt Sh and H357 CisR CMTM6 shRNA treated with vehicle control (UT) and cisplatin (10 μM) (CisT) for 24 h. We have included two independent biological replicates to identify the CMTM6 downregulation mediated global transcriptome changes. For ...
ORGANISM(S): Homo sapiens 
This study employs single-cell sequencing to identify rare, transient cisplatin-resistant subpopulations in OSCC, analyzing their gene expression and signaling pathways. By targeting these vulnerable cell states, we aim to develop combination therapies that prevent resistance emergence, enhancing ci...
ORGANISM(S): Homo sapiens 
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