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TranscriptomicsSelective inhibition of yeast regulons by daunorubicin
The antitumor drug daunorubicin exerts some of its cytotoxic effects by binding to DNA and inhibiting the transcription of different genes. We analysed this effect in vivo transcriptome level using the budding yeast Saccharomyces cerevisiae as a model and sublethal concentrations of the drug to min...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-18 | E-GEOD-19351 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary ALL cells (B-lineage) sensitive to daunorubicin by the MTT in vitro sensitivity assay
primary ALL cells (B-lineage) sensitive to daunorubicin by the MTT in vitro sensitivity assay
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-659 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary ALL cells (B- and T-lineage) resistant to daunorubicin by the MTT in vitro sensitivity assay
primary ALL cells (B- and T-lineage) resistant to daunorubicin by the MTT in vitro sensitivity assay
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-651 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary ALL cells (B-lineage) resistant to daunorubicin by the MTT in vitro sensitivity assayDNR resistant B-ALL
primary ALL cells (B-lineage) resistant to daunorubicin by the MTT in vitro sensitivity assay
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-660 | biostudies-arrayexpress
GenomicsAntiphage capacity of Daunorubicin
Studying the daunorubicin-mediated inhibition of the tequintavirus Bas33
PRJEB101990 | ENA
TranscriptomicsChanges in Gene Expression Profile in two Multidrug Resistant Cell Lines derived from a same Drug Sensitive Cell line
Resistance to chemotherapy is one of the most relevant aspects of treatment failure in cancer. Cell lines are used as models to study resistance. We analyze the transcriptional profile of two multidrug resistant (MDR) cell lines (Lucena 1 and FEPS) derived from the same drug-sensitive cell K562. Mic...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-57470 | biostudies-arrayexpress
TranscriptomicsA Pre-clinical model of induction therapy and relapse in pediatric acute lymphoblastic leukemia
The development of a clinically relevant xenograft model of pediatric acute lymphoblastic leukemia, using a 4-drug treatment regimen designed to mimic pediatric remission induction therapy. Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clin...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-MEXP-3916 | biostudies-arrayexpress
GenomicsSUMO-2/3 ChIP-Seq in HL-60 cells treated or not with Daunorubicin, Cytarabin and the Nox inhibitor VAS2870
Acute Myeloid Leukemia cell line HL-60 were treated with 1 M daunorubicin (DNR) or 2M cytarabin (Ara-C) or 1 M DNR + 10 M VAS2870 (NADPH oxidase inhibitor) for 2 hours. ChIP-Seq experiments were carried out with SUMO-2/3 antibodies. Immunoprecipitated DNA and corresponding inputs from 3 independent...
ORGANISM(S): Homo sapiens 
2023-12-30 | E-MTAB-4947 | biostudies-arrayexpress
TranscriptomicsExpression data of A375 melanoma cells after DMSO or MLN4924 +/- Nutlin treatment for 26 hours
Microarrays were used to determine the change in gene expression of genes involved in the p53 pathway after siRNA knock down of p53, CDT1 or BRCA1 A375 cells were grown, transfected with siRNA, incubated for 48hrs, then incubated for another 26hrs in the presence of either 0.065% DMSO as control, 65...
ORGANISM(S): Homo sapiens 
2012-07-03 | E-GEOD-39091 | biostudies-arrayexpress
TranscriptomicsSelective inhibition of yeast regulons by daunorubicin
The antitumor drug daunorubicin exerts some of its cytotoxic effects by binding to DNA and inhibiting the transcription of different genes. We analysed this effect in vivo transcriptome level using the budding yeast Saccharomyces cerevisiae as a model and sublethal concentrations of the drug to mini...
ORGANISM(S): Saccharomyces cerevisiae 
2009-12-08 | GSE19351 | GEO
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