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MetabolomicsA homeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism

Cellular senescence affects many physiological and pathological processes and is characterized by durable cell cycle arrest, an inflammatory secretory phenotype and metabolic reprogramming. Here, by using dynamic transcriptome and metabolome profiling in human fibroblasts with different subtypes ...

2024-01-09 | MTBLS7118 | MetaboLights
TranscriptomicsImpact of environmental pollutants on insecticide-driven gene selection in mosquitoes
This microarray study aimed at evaluating the impact of mosquito chemical environment on the selection of insecticide resistance mechanisms. Here the mosquito Aedes aegypti was used as a model to perform a laboratory experiment combining mosquito larvae exposure to a sub-lethal dose of xenobiotic an...
ORGANISM(S): Aedes aegypti 
2012-03-31 | E-MTAB-632 | biostudies-arrayexpress
UnknownPhase II study of gemcitabine, carboplatin, and bevacizumab in patients with advanced unresectable or metastatic urothelial cancer.
Not available
S-EPMC3574268 | biostudies-literature
UnknownOptimizing Tedizolid Dosing in Cerebral Nocardiosis: Clinical Impact of Direct Unbound Concentration Measurement and Population PK Modelling in Two Cases.
Not available
S-EPMC12852995 | biostudies-literature
GenomicsA GWAS in uveal melanoma identifies risk polymorphisms in the CLPTM1L locus.
Uveal melanoma, a rare malignant tumor of the eye, is predominantly observed in populations of European ancestry. A genome-wide association study of 259 uveal melanoma patients compared to 401 controls all of European ancestry revealed a candidate locus at chromosome 5p15.33 (region rs421284: OR = 1...
EGAS00001002334 | EGA
GenomicsUM_GWAS
Genotype cases using Illumina HumanOmni5
EGAD00010001463 | EGA
GenomicsData Access Committee for Institut Curie
Data Access Committee EGAC00001000670
EGAC00001000670 | EGA
UnknownFAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer
Not available
S-SCDT-EMM-2020-12010 | biostudies-other
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