Sort   by:  
 Page size 
TranscriptomicsMC EMiNEM Maps the Interaction Landscape of the Mediator
By applying MC EMiNEM (a novel method based on the concept of Nested Effects Models (NEMs) for the retrieval of functional dependencies between proteins that have pleiotropic effects on mRNA transcription) to the expression data from four gene perturbation studies (three of them unpublished) in Sacc...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-01 | E-MTAB-1037 | biostudies-arrayexpress
GenomicsMutational patterns and regulatory networks in epigenetic subgroups of meningioma (H033)
DNA methylation patterns delineate clinically relevant subgroups of meningioma. We previously established the six meningioma methylation classes (MC) benign-1, 2, 3, intermediate-A, B and malignant. Here, we set out to identify subgroup-specific mutational patterns and pathway regulation. Whole-gen...
EGAS00001003481 | EGA
TranscriptomicsImatinib targeting of KIT-mutant oncoprotein in melanoma
Metastatic melanoma is an aggressive treatment-refractory malignancy. Recently, c-Kit mutations were discovered in certain mucosal melanomas. A clinical trial was initiated with the c-Kit inhibitor imatinib mesylate. The first treated patient experienced dramatic clinical improvement within days, f...
ORGANISM(S): Homo sapiens 
2008-12-23 | E-GEOD-8164 | biostudies-arrayexpress
UnknownA safety mechanism enables tissue-specific resistance to protein aggregation during aging in C. elegans.
Not available
S-EPMC10501630 | biostudies-literature
UnknownHepatic decompensation in antiretroviral-treated patients co-infected with HIV and hepatitis C virus compared with hepatitis C virus-monoinfected patients: a cohort study.
Not available
S-EPMC4254786 | biostudies-literature
MetabolomicsHost-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), a devastating neglected tropical disease. However, further medicinal development is largely restric...
2018-02-12 | MTBLS452 | MetaboLights
UnknownRisk of Acute Liver Injury After Statin Initiation by Human Immunodeficiency Virus and Chronic Hepatitis C Virus Infection Status.
Not available
S-EPMC5850026 | biostudies-literature
TranscriptomicsTranscriptome profiling in 6-hydroxydopamine hemiparkinsonian rats reveals methamphetamine-mediated dopamine-independent changes in striatal gene expression.
Unilateral injections of 6-hydroxydopamine into the medial forebrain bundle (MFB) is used extensively as a model of Parkinson’s disease. The present experiments examined whether a single injection of methamphetamine (METH) (2.5 mg/kg) could still influence striatal gene expression after 6-hydroxydop...
ORGANISM(S): Rattus norvegicus 
2010-09-21 | E-GEOD-24233 | biostudies-arrayexpress
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
UnknownFIB-4 stage of liver fibrosis is associated with incident heart failure with preserved, but not reduced, ejection fraction among people with and without HIV or hepatitis C.
Not available
S-EPMC7278895 | biostudies-literature
Sort   by:  
 Page size