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ProteomicsPolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons
A GGGGCC repeat expansion in C9orf72 is the most common genetic cause of ALS and FTD (C9ALS/FTD). Dipeptide repeat (DPR) proteins, generated by translation of the expanded repeat, are a major pathogenic feature of C9ALS/FTD pathology, but their physiological impact has yet to be fully determined. He...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-04 | PXD047502 | Pride
Tgf-β Collagen vi Frontotemporal dementia Amyotrophic lateral sclerosis Proteomics Col6a1 C9orf72 Extracellular matrix 
TranscriptomicsTranscription profiling of human aortic endothelial cells, HAEC treated with TNF-alpha amplified aRNA samples vs unamplified RNA samples
Fidelity of TNF-alpha induced differential gene expression in amplified aRNA samples relative to unamplified RNA samples (human aortic endothelial cells, HAEC).
ORGANISM(S): Homo sapiens 
2005-08-19 | E-CBIL-3 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pig aortic endothelial cells to investigate the impact of gender, high fat/high cholesterol diet and regional hemodynamics on gene expression
Atherosclerosis preferentially develops in susceptible regions of the arterial system that are defined by the regional vascular hemodynamics. Previous work in adult castrate male pigs revealed the coexistence of pro- and anti-atherosclerotic profiles in endothelial cell gene expression in disturbed ...
ORGANISM(S): Sus scrofa 
2007-12-15 | E-CBIL-41 | biostudies-arrayexpress
UnknownFeasibility of collecting longitudinal patient-reported outcomes in individuals with relapsed or refractory large B-cell lymphoma who received chimeric antigen receptor T-cell (CART) therapy.
Not available
S-EPMC11312407 | biostudies-literature
UnknownDisrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen.
Not available
S-EPMC8655499 | biostudies-literature
MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
UnknownTrends in low global warming potential inhaler prescribing: A UK-wide cohort comparison from 2018-2024.
Not available
S-EPMC11842734 | biostudies-literature
UnknownGuillain-Barre Syndrome Following Zika Virus Infection Is Associated With a Diverse Spectrum of Peripheral Nerve Reactive Antibodies.
Not available
S-EPMC9679884 | biostudies-literature
UnknownLongitudinal Pharmacokinetic-Pharmacodynamic Biomarkers Correlate With Treatment Outcome in Drug-Sensitive Pulmonary Tuberculosis: A Population Pharmacokinetic-Pharmacodynamic Analysis.
Not available
S-EPMC7378673 | biostudies-literature
TranscriptomicsTranscription profiling time series of Bacillus cereus from cultures grown in media with bile salts
RNA was isolated from control and bile salt cultures 15, 30, and 60 minutes after shift (named C15,C30,C60 and BC15,BS30,BS60, repectively) and hybridized against the reference RNA (C0) isolated immediatly after the shift.
ORGANISM(S): Bacillus cereus 
2007-05-17 | E-MEXP-896 | biostudies-arrayexpress
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