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MetabolomicsNPC1 regulates the distribution of phosphatidylinositol 4 kinases at Golgi and Lysosome membranes
Cholesterol and phosphoinositides (PI) are two critically important lipids that are found in cellular membranes and dysregulated in many disorders. Therefore, uncovering molecular pathways connecting these essential lipids may offer new therapeutic insights. We report that loss of function of lysoso...
2021-09-15 | MTBLS2612 | MetaboLights
TranscriptomicsComparative transcriptomics of Central Asian Vitis vinifera accessions reveals distinct defense strategies against powdery mildew
Grape powdery mildew (PM), caused by the biotrophic ascomycete Erysiphe necator, is a devastating fungal disease that affects most Vitis vinifera cultivars. We have previously identified a panel of V. vinifera accessions from Central Asia with partial resistance to PM that possess a Ren1-like local ...
ORGANISM(S): Vitis vinifera subsp. silvestris 
2015-07-20 | E-GEOD-67191 | biostudies-arrayexpress
UnknownPilot study of levodopa dose as treatment for residual amblyopia in children aged 8 years to younger than 18 years.
Not available
S-EPMC3137458 | biostudies-literature
UnknownTwo Influential Primate Classifications Logically Aligned.
Not available
S-EPMC4911943 | biostudies-literature
UnknownImpact of Surveillance Imaging Modality on Survival After Recurrence in Patients With Favorable-Histology Wilms Tumor: A Report From the Children's Oncology Group.
Not available
S-EPMC6269130 | biostudies-literature
TranscriptomicsGene expression in Maize root region 1 at low water potential
Previous work showed that the maize primary root adapts to low water potential (-1.6 MPa) by maintaining longitudinal expansion in the apical 3 mm (region 1), whereas in the adjacent 4 mm (region 2) longitudinal expansion reaches a maximum in well-watered roots but is progressively inhibited at low ...
ORGANISM(S): Zea mays 
2010-05-26 | E-GEOD-9341 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse day 5 5cc7 T cell blasts
Our aim was to get a general sense of which proteins are expressed in 5cc7 T cell blasts. We use these cells for a number of different experiments in our lab Experiment Overall Design: RNA was isolated from day 5 5cc7 T cell blasts. This RNA was converted to cRNA and used to hybridize 2 affymetrix...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-4050 | biostudies-arrayexpress
GenomicsCell cycle transition from S-phase to G1 in Caulobacter is mediated by ancestral virulence regulators
We report that ancestral zinc-finger-domain transcriptional regulators, previously reported to control virulence/symbiosis, implement a cell cycle (SM-bM-^FM-^RG1) transcriptional switch. To unravel how this G1-phase transcriptional program is reinstated during a primitive cell cycle, we first de...
ORGANISM(S): Sinorhizobium fredii 
2014-05-25 | E-GEOD-52849 | biostudies-arrayexpress
TranscriptomicsBaseline expression from transcriptional profiling of zebrafish developmental stages
Establish baseline expression transcriptional signatures for zebrafish developmental stages. Total RNA was extracted from single wild type zebrafish embryos at a series of different developmental stages. RNA from 12 embryos was pooled to generate a replicate.The RNA was DNase treated. Stranded RNAs...
ORGANISM(S): Danio rerio 
2016-06-12 | E-ERAD-475 | biostudies-arrayexpress
ProteomicsQuantification of Raloxifene Specific 471 Da Adducts in CYP3A4 and P450-Reductase
Drugs are often metabolized to reactive intermediates that form protein adducts. Adducts can inhibit critical proteins, elicit immune responses, and cause life threatening adverse drug reactions. The masses of metabolites are frequently unknown, rendering traditional mass spectrometry-based proteomi...
ORGANISM(S): Homo Sapiens Rattus Norvegicus 
2022-02-21 | PXD024932 | panorama
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