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TranscriptomicsExpression data from murine colon tissue after exposure to 4% DSS for 6 days DSS followed by 4 days of water or 1% L-arginine
L-Arginine (L-Arg) is the substrate for both inducible nitric oxide synthase and arginase, which are upregulated in human IBD and in mouse colitis models. We have found that L-Arg supplementation enhances wound restitution in vitro, and improves the clinical parameters of weight loss, survival, and ...
ORGANISM(S): Mus musculus 
2012-06-26 | E-GEOD-34874 | biostudies-arrayexpress
TranscriptomicsSmall molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation. Reprogramming of the ER proteostasis environment through genetic activation of the Unfolded Protein Response (UP...
ORGANISM(S): Homo sapiens 
2016-07-21 | E-GEOD-84636 | biostudies-arrayexpress
TranscriptomicsGlobal phenotypic and genomic comparison of two Saccharomyces cerevisiae wine strains
The aim of this study is to phenotype a collection of 27 S. cerevisiae commercial wine strains growing within temperatures (4-45ºC) in both minimal media (SD) and synthetic must (SM) and, taking into account µmax value, to select two strains with divergent phenotype in their capacity to grow at low ...
ORGANISM(S): Saccharomyces cerevisiae 
2015-03-31 | E-GEOD-60140 | biostudies-arrayexpress
TranscriptomicsReal-time quantitative PCR analysis of mRNA from the colon of WT, Nod2-/-, Pglyrp3-/-, and Pglyrp3-/-Nod2-/- mice treated with oral DSS
Wild type (WT), Nod2-/-, Pglyrp3-/-, and Pglyrp3-/-Nod2-/- mice (BALB/c) were treated with oral 5% dextran sodium sulfate (DSS) for 48, 72, or 96 hrs, their colons were removed and homogenized, and RNA was isolated using the TRIZOL method. Quantitative reverse transcription real-time PCR (qRT-PCR) w...
ORGANISM(S): Mus musculus 
2014-08-08 | E-GEOD-47588 | biostudies-arrayexpress
TranscriptomicsColon mucosa of F344 rats: control treated with 5% DSS vs Resveratrol + 5% DSS
Expression profile of colon mucosa of F344 rats treated with 5% DSS during five days vs colon mucosa of F344 rats pre-treated for 20 days with resveratrol 1mg/kg/day and during the five days of 5% DSS administration Keywords: Inflammation experiment Two conditions experiment, colon mucosa of F344 r...
ORGANISM(S): Rattus norvegicus 
2009-01-27 | E-GEOD-14544 | biostudies-arrayexpress
TranscriptomicsColonic gene expression data of TIMP1 knock out colitis mice
Increased levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) have been detected in fibrotic strictures in Crohn’s disease. In a murine model of chronic inflammation, fibrosis was associated with an increase in TIMP-1 and inhibition of matrix metalloproteinase (MMP)-mediated degradation. We...
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-73424 | biostudies-arrayexpress
TranscriptomicsBulk RNA-Sequencing of defined brain regions of mice with acute DSS-induced colitis
Selected brain regions of mice with acute DSS colitis and controls to study the impact of gut inflammation on the brain
ORGANISM(S): Mus musculus 
2026-01-01 | E-MTAB-15489 | biostudies-arrayexpress
TranscriptomicsBulk RNA-Sequencing of brain hemispheres of mice with acute DSS-induced colitis
Whole right brain hemispheres of mice with acute DSS colitis and controls to study the impact of gut inflammation on the brain
ORGANISM(S): Mus musculus 
2026-01-01 | E-MTAB-15482 | biostudies-arrayexpress
TranscriptomicsRNA-Seq data from epiphyseal growth plates of young male rats, healthy control rats and dextran sodium sulfate (DSS) induced colitis treated rats
Growth failure is a major complication of pediatric inflammatory bowel disease (IBD), a condition whose prevalence has risen sharply over recent decades. Despite advances in medical therapy, linear growth impairment often persists. This underscores the urgent need to elucidate how chronic inflammati...
ORGANISM(S): Rattus norvegicus 
2025-11-29 | E-MTAB-16246 | biostudies-arrayexpress
TranscriptomicsGene expression profile after Dax1 deletion in ES cells
To investigate the function of Dax1 in mouse ES cells, whole genome microarray expression profiling was employed to identify genes that are potentially affected by the deletion of Dax1. An inducible knockout ES cell line of Dax1 with the Cre-loxP system was generated and gene expression was measured...
ORGANISM(S): Mus musculus 
2015-05-13 | E-GEOD-61152 | biostudies-arrayexpress
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