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TranscriptomicsFormaldehyde-induced changes in microRNA signaling [Agilent]
MicroRNAs (miRNAs) are critical regulators of gene expression, yet much remains unknown regarding miRNA changes resulting from environmental exposures and whether they influence pathway signaling across various tissues and time. To gain knowledge on these novel topics, we set out to investigate in v...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-42393 | biostudies-arrayexpress
TranscriptomicsFormaldehyde-induced changes in microRNA signaling [Affymetrix]
In addition to gaining knowledge on in vivo miRNA responses to formaldehyde, we set out to relate these miRNA responses to transcriptional profiles modified by formaldehyde. Rats were exposed by inhalation to either 0 or 2 ppm formaldehyde (6 hours/day) for 28 days. Genome-wide transcriptional profi...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-42394 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling permits the identification of pollutant sources and effects in ambient water samples
The delta smelt (Hypomesus transpacificus) is a pelagic fish species endemic to the Sacramento-San Joaquin Estuary in Northern California, listed as endangered under both the USA Federal and Californian State Endangered Species Acts and acts as an indicator of ecosystem health in its habitat range. ...
ORGANISM(S): Hypomesus transpacificus 
2012-09-20 | E-GEOD-40991 | biostudies-arrayexpress
TranscriptomicsRole of epigenetic modifiers on the bovine fibroblast innate immune response
The innate immune signaling pathway plays a crucial role in the recognition and early response to pathogens associated with disease. Genetic analysis has been unable to completely account for individual variability in the strength of the innate immune response. The aim of this study was to determine...
ORGANISM(S): Bos taurus 
2014-01-01 | E-GEOD-50405 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of ex vivo isolated inflammed mouse lymphatic endothelial cells
Chemokines and adhesion molecules upregulated in lymphatic endothelial cells (LECs) during tissue inflammation are believed to enhance dendritic cell (DC) migration to draining lymph nodes (dLNs), but the in vivo control of this process is not well understood. By performing transcriptional profiling...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-26229 | biostudies-arrayexpress
TranscriptomicsSubmerged differentiation of Aspergillus niger in carbon-limited cultures approaching zero specific growth rate
This work presents an exploration of submerged differentiation of the ubiquitous saprophyte and industrially important fungus, Aspergillus niger, in response to a limited availability of a sole carbon and energy source, maltose. In aspergilli and other mold fungi, asexual reproduction through format...
ORGANISM(S): Aspergillus niger 
2010-07-07 | E-GEOD-21752 | biostudies-arrayexpress
TranscriptomicsExpression data from primary osteoblasts isolated from calvaria of Gnptab(c.3082insC) knock-in mice compared with osteoblasts isolated from wild-type littermates
Mucolipidosis type II (MLII) is a severe inherited multisystemic disorder caused by mutations in the GNPTAB gene. Skeletal abnormalities are a predominant feature of MLII. Here we investigate the gene expression in a knock-in mouse model for mucolipidosis type II, generated by the insertion of a cyt...
ORGANISM(S): Mus musculus 
2014-01-29 | E-GEOD-43854 | biostudies-arrayexpress
TranscriptomicsGene profiling of v-Src transformed primary chicken cells
Cell transformation by the Src tyrosine kinase is characterized by extensive changes in gene expression. To describe these changes, investigators have relied extensively on the study of immortalized rodent cell lines or heterogeneous tumor samples that limit the identification of differentially exp...
ORGANISM(S): Gallus gallus 
2010-02-21 | E-GEOD-14489 | biostudies-arrayexpress
TranscriptomicsAge-dependent gene and protein expression following transection of neonatal spinal cord of Monodelphis domestica (South American Grey Short-tailed opossum)
In the present study we investigated the genome and the proteome in the segment of cord rostral to the site of injury following a complete spinal cord transection in opossums at an age when axonal growth across a lesion and substantially normal locomotor development occur (postnatal day 7, P7) and c...
ORGANISM(S): Monodelphis domestica 
2015-02-10 | E-GEOD-54805 | biostudies-arrayexpress
TranscriptomicsThe let-7-Imp axis regulates aging of the Drosophila testis stem cell niche.
Adult stem cells support tissue homeostasis and repair throughout the life of an individual. However, numerous intrinsic and extrinsic changes occur with age that result in altered stem cell behavior and reduced tissue maintenance and regeneration. In the Drosophila testis, stem cells surround and c...
ORGANISM(S): Drosophila melanogaster 
2012-05-31 | E-GEOD-37041 | biostudies-arrayexpress
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