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ProteomicsQuantitative tissue proteomics reveals increased pathogenesis associated with infection with the SARS-CoV-2 Delta variant that is independent of viral infectivity in Syrian golden hamsters
Background: Since its emergence in 2020, circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been dominated by waves of genetically distinct variants with varying pathogenicity. Understanding the molecular mechanisms underlying SARS-CoV-2 pathogenesis, and the host and viral...
ORGANISM(S): Mesocricetus auratus (Golden hamster) 
2026-01-26 | PXD054808 | Pride
Sars-cov-2 Proteomics Hamster Phosphoproteomics Pathogenesis 
UnknownEpacadostat Plus Pembrolizumab in Patients With Advanced Solid Tumors: Phase I Results From a Multicenter, Open-Label Phase I/II Trial (ECHO-202/KEYNOTE-037).
Not available
S-EPMC6225502 | biostudies-literature
UnknownPrevention of pegfilgrastim-induced bone pain: a phase III double-blind placebo-controlled randomized clinical trial of the university of rochester cancer center clinical community oncology program research base.
Not available
S-EPMC3383174 | biostudies-literature
UnknownImatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin.
Not available
S-EPMC4878082 | biostudies-literature
UnknownRandomized phase III trial of induction chemotherapy with docetaxel, cisplatin, and fluorouracil followed by surgery versus up-front surgery in locally advanced resectable oral squamous cell carcinoma.
Not available
S-EPMC5569675 | biostudies-literature
ProteomicsTargeted mass spectrometry enables multiplexed quantification of immunomodulatory proteins in clinical biospecimens
Immunotherapies are revolutionizing cancer care, producing durable responses and potentially cures in a subset of patients. However, response rates are low for most tumors, grade 3/4 toxicities are not uncommon, and our current understanding of tumor immunobiology is incomplete. While hundreds of im...
ORGANISM(S): Homo Sapiens 
2022-02-28 | PXD029167 | panorama
ProteomicsQuantification of HER2 by Immunopeptide Enrichment and Targeted Mass Spectrometry in Formalin-Fixed Paraffin-Embedded (FFPE) and Frozen Breast Cancer Tissues
Background: Conventional HER2-targeting therapies improve outcomes for patients with HER2-positive breast cancer (BC), defined as tumors showing HER2 protein overexpression by an immunohistochemistry (IHC) assay and/or ERBB2 gene amplification determined by in situ hybridization (ISH). Emerging HER2...
ORGANISM(S): Homo Sapiens 
2021-07-07 | PXD021893 | panorama
UnknownInterleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19.
Not available
S-EPMC7953461 | biostudies-literature
UnknownTherapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.
Not available
S-EPMC8362592 | biostudies-literature
UnknownAzithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC7884931 | biostudies-literature
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