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GenomicsWhole Genome Scan for Pancreatic Cancer Risk in the Pancreatic Cancer Cohort Consortium and Pancreatic Cancer Case-Control Consortium (PanScan)

Within the framework of the NCI-sponsored Cohort Consortium, investigators from 12 prospective epidemiologic cohorts formed the Pancreatic Cancer Cohort Consortium in 2006. This study, also known as "PanScan", is funded by the National Cancer Institute (NCI) and involves conducting a genome-w...

phs000206.v3.p2 | EGA
TranscriptomicsUncovering Genes and Regulatory Pathways Related to Urinary Albumin Excretion in Mice
Identifying the genes underlying quantitative trait loci (QTL) for disease has proven difficult, mainly due to the low resolution of the approach and the complex genetics involved. However, recent advances in bioinformatics and the availability of genetic resources now make it possible to narrow the...
ORGANISM(S): Mus musculus 
2011-02-01 | E-GEOD-23310 | biostudies-arrayexpress
TranscriptomicsRNAseq analysis of Chrnb4-cre driven Dicer conditional knockout (Dicer CKO) whole retinas
We have shown that Chrnb4-cre; Dicerflox/flox retinas (Dicer CKO) display a cone dystrophy by postnatal day P21, independent of rod degeneration. To elucidate which gene pathways were affected by Dicer loss, RNA sequencing was performed in whole neural retinas of P21 control and Dicer CKO mice. This...
ORGANISM(S): Mus musculus 
2019-01-14 | E-MTAB-6133 | biostudies-arrayexpress
TranscriptomicsmiRNAseq analysis of Chrnb4-cre driven Dicer conditional knockout (Dicer CKO) whole retinas
We have shown that Chrnb4-cre; Dicerflox/flox retinas (Dicer CKO) display a cone dystrophy by postnatal day P21, independent of rod degeneration. To elucidate which miRNAs were involved in such phenotype, miRNA sequencing was performed in whole retinas of P21 and 3.5 month old control and Dicer CKO ...
ORGANISM(S): Mus musculus 
2019-01-14 | E-MTAB-6132 | biostudies-arrayexpress
TranscriptomicsPla2g12b and Hpn are Genes Identified by Mouse ENU Mutagenesis that affect HDL cholesterol
Despite considerable progress understanding genes that affect the HDL particle, its function, and cholesterol content, genes identified to date explain only a small percentage of the genetic variation. We used N-ethyl-N-nitrosourea mutagenesis in mice to discover novel genes that affect HDL choleste...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-37902 | biostudies-arrayexpress
TranscriptomicsMRLxSM eQTL in Liver by RMA on Ensembl transcripts
A QTL analysis between inbred mouse strains MRL/MpJ and SM/J was performed to identify genetic loci influencing high-density lipoprotein (HDL) cholesterol and triglycerides (TG) at eight weeks of age in F2 mice fed a chow diet. In order to narrow down lists of candidate genes, expression levels from...
ORGANISM(S): Mus musculus 
2011-11-28 | E-GEOD-25322 | biostudies-arrayexpress
ProteomicsConcentration determination of >200 proteins in dried blood spots for biomarker discovery and validation
Raw files were created using XCalibur 3.0.63 (Thermo Scientific) software and analysed with Thermo Proteome Discoverer 2.2.0.388 software suite (Thermo Scientific). The raw data files were processed as previously described 26 with the following modifications: the peak lists were submitted to Mascot...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-11-27 | MSV000084629 | MassIVE
TranscriptomicsMicroRNA discovery and profiling in human embryonic stem cells by deep sequencing of small RNA libraries
We used massively parallel pyrosequencing to discover and characterize microRNAs (miRNAs) expressed in human embryonic stem cells (hESCs). Sequencing of small RNA cDNA libraries derived from undifferentiated hESC and from isogenic differentiating cultures yielded a total of 425,505 high-quality sequ...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-21722 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human invasive breast cancer carcinomas with different histological types and invasive lobular carcinoma
Gene expression array analysis on a series of ten different histological special types of invasive breast carcinomas (tubular, micropapillary, mucinous A, mucinous B, endocrine, apocrine, metaplastic, medullary, adenoid cystic, invasive ductal carcinoma with osteoclastic giant cells) and invasive lo...
ORGANISM(S): Homo sapiens 
2010-08-20 | E-NCMF-3 | biostudies-arrayexpress
UnknownGlobal hospital-based disease management of acute diverticulitis: a prospective, international cohort study.
Not available
S-EPMC12512976 | biostudies-literature
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