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TranscriptomicsEffector cell signatures in peripheral blood after nasal allergen challenge: biomarkers of the allergic response
This study investigated temporal transcriptomic changes in response to nasal allergen challenge of titrated timothy grass pollen. This is an open single-center observational study conducted outside the pollen season. Twelve participants with seasonal allergic rhinitis underwent a control (diluent) c...
ORGANISM(S): Homo sapiens 
2013-01-16 | E-GEOD-43497 | biostudies-arrayexpress
ProteomicsCharacterization of Bovine Dry Secretions and their Proteome from the End of Lactation Through Day 21 of the Dry Period
The dry period in cow are critical to mammary health and the success of the next lactation. The expression of proteins the dry period progresses need to be characterized to provide information on involution and immune functions during the dry period. Total protein and lactoferrin concentrations ros...
ORGANISM(S): Bos taurus (Bovine) 
2020-05-20 | PXD017837 | Pride
Mastitis Mammary involution Proteome Dairy cow dry period Bovine dry secretions 
MetabolomicsChanges in lipid profiles of epileptic mouse model

INTRODUCTION: Approximately 1% of the world's population is impacted by epilepsy, a chronic neurological disorder characterized by seizures. One-third of epileptic patients are resistant to AEDs, or have medically refractory epilepsy (MRE). One non-invasive treatment that exists...

2022-01-06 | MTBLS1432 | MetaboLights
Transcriptomics5-azacytidine and entinostat treatment of patients with MDS, chronic myelomonocytic leukemia (CMMoL), and high risk AML
Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies. The patients with MDS, chronic myelomonocytic leukemia (CMMoL), and high risk AML were treated with sequential administration of ...
ORGANISM(S): Homo sapiens 
2009-06-20 | E-GEOD-16625 | biostudies-arrayexpress
MetabolomicsTranscript, protein and metabolite temporal dynamics in the CAM plant Agave
Already a proven mechanism for drought sustainability, crassulacean acid metabolism (CAM) is a specialized type of photosynthesis that maximizes water-use efficiency (WUE) via an inverse (compared to C3 and C4 photosynthesis-performing species) day/night pattern of stomatal closure/opening to shift ...
2017-10-13 | MTBLS363 | MetaboLights
TranscriptomicsGene expression profiling of Schistosoma mansoni larval development using serial analysis of gene expression (SAGE)
Biomphalaria glabrata infection by the Schistosoma mansoni free-swimming miracidium and its subsequent development to the parasitic sporocyst stage is critical to establishment of viable infections and triggers a variety of physiological, biochemical and molecular changes. Here, we describe a genom...
ORGANISM(S): Schistosoma mansoni 
2009-03-09 | E-GEOD-9722 | biostudies-arrayexpress
GenomicsMorphine treatment induces distinct changes in the gut microbiome at day 3 post treatment
Opioids such as morphine have many beneficial properties as analgesics, however, opioids may induce multiple adverse gastrointestinal symptoms. We have recently demonstrated that morphine treatment results in significant disruption in gut barrier function leading to increased translocation of gut co...
ORGANISM(S): mouse gut metagenome 
2018-04-16 | E-MTAB-5546 | biostudies-arrayexpress
TranscriptomicsDivergent genome wide transcriptional profiles from immune cell subsets isolated from SLE patients with different ancestral backgrounds
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex multi-system autoimmune disease of uncertain etiology. Patients from different ancestral backgrounds demonstrate differences in clinical manifestations and autoantibody profiles. In this study we examined genome-wide transcription...
ORGANISM(S): Homo sapiens 
2015-05-15 | E-GEOD-55447 | biostudies-arrayexpress
UnknownRandomized phase III multi-institutional study of TNFerade biologic with fluorouracil and radiotherapy for locally advanced pancreatic cancer: final results.
Not available
S-EPMC4820756 | biostudies-literature
TranscriptomicsThe Presomitic Mesoderm (PSM) CREB family transcriptome
Dynamic gene expression in the PSM of vertebrates is critical for the spatial and temporal patterning of somites. Using microarray analysis, we explored in detail, genes that are differentially regulated upon removal of CREB family function from the mouse PSM. Mouse PSM from R26R^AC/AC (Control) and...
ORGANISM(S): Mus musculus 
2013-04-27 | E-GEOD-46426 | biostudies-arrayexpress
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