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MetabolomicsDeletion of glycerol channel aquaporin-9 (Aqp9) impairs long-term blood glucose control in C57BL/6 leptin receptor-deficient (db/db) obese mice
Deletion of the glycerol channel aquaporin-9 (Aqp9) reduces postprandial blood glucose levels in leptin receptor deficient (db/db) obese mice on a C57BL/6×C57BLKS mixed genetic background. Furthermore, shRNA mediated reduction of Aqp9 expression reduces liver triacylglycerol (TAG) accumulation in a ...
2015-09-28 | MTBLS219 | MetaboLights
TranscriptomicsGene expression changes in aortas of db/db versus control db/+ mice
To determine effects of hyperglycemia and insulin resistance on arterial wall biology, aortic gene expression profiles were generated using aortas from Lepr^db/db and their respective nondiabetic Lepr^db/+ controls. Keywords: Chip Experiment was done in triplicate with three independent pool of tes...
ORGANISM(S): Mus musculus 
2011-12-23 | E-GEOD-6733 | biostudies-arrayexpress
Metabolomicsdb/db WT ozone and air exposed mice
Not available
ORGANISM(S): Mus musculus 
ST000815 | MetabolomicsWorkbench
TranscriptomicsExpression data from livers of F2 mice (B57BL/6 X DBA/2) deficient in leptin receptor (db/db)
In several models of obesity-induced diabetes, increased lipid accumulation in the liver has been associated with decreased diabetes susceptibility. For instance, deficiency in leptin receptor (db/db) leads to hyperphagia and obesity in both C57BL/6 and C57BLKS mice but, only on the C57BLKS backgrou...
ORGANISM(S): Mus musculus 
2011-12-29 | E-GEOD-30140 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of the effect of metformin (50mg/kg,400mg/kg) on gene expression in livers of db/db mice
Effect of metformin (50mg/kg,400mg/kg) on gene expression in livers of db/db mice.
ORGANISM(S): Mus musculus 
2006-11-18 | E-MEXP-490 | biostudies-arrayexpress
GenomicsMus musculus strain:db/db
Mus musculus strain:db/db Raw sequence reads
PRJNA1091037 | ENA
TranscriptomicsProfiling pancreatic islets from obese db/db and lean control db/+ mice
This program addresses the molecular basis of beta-cell failure associated with the development of type 2 diabetes in the db/db mice. Specifically, which genes are differentially expressed in pancreatic islets of the db/db mice compared to the control db/+ mice? The db/db mice islets profiling data ...
ORGANISM(S): Mus musculus 
2013-03-22 | E-GEOD-31953 | biostudies-arrayexpress
TranscriptomicsProfiling epididymal white adipose tissue (eWAT) from obese db/db and lean control db/+ mice
This program addresses the gene signature associated with the development of type 2 diabetes in the db/db mice. Specifically, which genes are differentially expressed in adipose tissue of the db/db mice compared to the control db/+ mice? The db/db mice eWAT profiling data was analyzed by identifying...
ORGANISM(S): Mus musculus 
2013-03-22 | E-GEOD-38082 | biostudies-arrayexpress
ProteomicsdbdbLiraglutide - Effects of insulin and the glucagon-like peptide 1 receptor agonist liraglutide on the kidney proteome in db/db mice
db/db mouse kidney given liraglutide or insulin compared to db/db vehicle and healthy vehicle, 12 weeks dosing, all included db/db mice over 16 mM blood glucose level.
ORGANISM(S): Mus musculus (Mouse) 
2017-03-29 | PXD002988 | Pride
Liraglutide Opls Db/db Kidney Diabetic nephropathy 
TranscriptomicsBenefits of a 6 week supplementation of sebacic acid on a mouse model of type 2 diabetes (db/db mice)
This study aimed at investigating the impact of chronic ingestion of sebacic acid (SA), a 10 carbons medium-chain dicarboxylic acid, on glycemic control in a mouse model of type 2 diabetes (db/db mice). Three groups of 15 mice were fed for 6 weeks either a chow diet (Ctrl), or a chow diet supplement...
ORGANISM(S): Mus musculus 
2010-10-29 | E-GEOD-21083 | biostudies-arrayexpress
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